35677-87-3

Usage

Uses

Used in Pharmaceutical Industry:
1-ACETYL-2-PIPERIDINECARBOXYLIC ACID is used as an intermediate in the synthesis of various pharmaceuticals for its potential to contribute to the development of new medicines and drugs. Its unique structure and properties make it a valuable component in the creation of therapeutic agents.
Used in Academic and Industrial Research:
1-ACETYL-2-PIPERIDINECARBOXYLIC ACID is used as a building block for the synthesis of other chemical compounds in research settings. Its versatility in chemical reactions and potential for yielding new compounds of interest makes it an essential tool for scientists exploring novel chemical entities and their applications.

InChI:InChI=1/C8H13NO3/c1-6(10)9-5-3-2-4-7(9)8(11)12/h7H,2-5H2,1H3,(H,11,12)

Upstream product

• 63050-18-0 1-acetyl-2-methoxy-piperidine 
• 4043-87-2 pipecolic Acid 
• 108-24-7 acetic anhydride 
• 77873-79-1 1-[2-(5-Methyl-furan-2-yl)-piperidin-1-yl]-ethanone 

Downstream Products

• 1608501-56-9 1-acetyl-N-[5-(6-benzenesulfonamidopyridin-2-yl)-4-methyl-1,3-thiazol-2-yl]piperidine-2-carboxamide 

Relevant academic research and scientific papers

Bio- And Medicinally Compatible α-Amino-Acid Modification via Merging Photoredox and N-Heterocyclic Carbene Catalysis

An N-heterocyclic carbene and photoredox cocatalyzed α-amino-acid decarboxylative carbonylation reaction is presented. This method displays good scope generality, providing a direct pathway to access various downstream α-amino ketones under bio- and medicinally compatible conditions. Moreover, this strategy is appealing to chemical biology because it has great potential for the chemical modification of peptides or the late-stage synthesis of keto-peptides.

Inhibitors of an essential mycobacterial cell wall lipase (Rv3802c) as tuberculosis drug leads

The first targeted inhibitors of an essential M. tuberculosis cell wall lipase, Rv3802c, are described. Lead compounds exhibited nanomolar inhibition of the enzyme, and encouraging antibacterial activity against M. tuberculosis in vitro, supporting Rv3802c as a novel TB drug target.

Tricyclic compounds

Novel compounds of Formula STR1 are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the formula to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.

Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases

A method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells is disclosed. The method comprises the administration of a compound of Formula 1.0: STR1 to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being. Novel compounds of formulas 5.0, 5.1 and 5.2, wherein R is --C(R20)(R21)(R46), and 5.3, 5.3A and 5.3B, wherein R is --N(R25)(R48), are disclosed. Also disclosed are processes for making 3-substituted compounds of Formulas 5.0, 5.1, 5.2 and 5.3. Further disclosed are novel compounds which are intermediates in the process for making 3-substituted compounds of Formulas 5.0, 5.1, 5.2 and 5.3.

Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases

Novel compounds of Formula (7.0a), (7.0b) or (7.0c): STR1 are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the formula (7.0a), (7.0b) or (7.0c) to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.

NEW SYNTHESIS OF PIPECOLIC ACID AND ANALOGS

Pipecolic acid congeners are synthesised from α-cyanoamides, obtained by substitution of α-methoxyamides with trimethylsilyl cyanide and in an alternative route via oxidation of amidoalkylationproducts of the α-methoxyamides.