356788-71-1

Basic information

• Product Name: [L-(trans)]-4-[(t-butoxycarbonyl)amino]-2-methyl-5-phenyl-2-pentenoic acid
• Synonyms: [L-(trans)]-4-[(t-butoxycarbonyl)amino]-2-methyl-5-phenyl-2-pentenoic acid
• CAS NO: 356788-71-1
• Molecular Weight: 305.374
• Mol File: 356788-71-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: [L-(trans)]-4-[(t-butoxycarbonyl)amino]-2-methyl-5-phenyl-2-pentenoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [L-(trans)]-4-[(t-butoxycarbonyl)amino]-2-methyl-5-phenyl-2-pentenoic acid(356788-71-1)
• EPA Substance Registry System: [L-(trans)]-4-[(t-butoxycarbonyl)amino]-2-methyl-5-phenyl-2-pentenoic acid(356788-71-1)

Safety Data

• Hazardous Substances Data: 356788-71-1(Hazardous Substances Data)

Upstream product

• 244033-72-5 (4S)-4-N-tert-butoxycarbonylamino-5-phenyl-2-methyl-2-trans-pentenoic acid, ethyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 72155-45-4 Boc-L-phenylalaninal 
• 30094-28-1 2-(diethylphosphono)propionic acid 
• 51987-73-6 (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester 
• 66605-57-0 (S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol 

Downstream Products

• 1219930-75-2 methyl (2S,4R)-2-methyl-4-[({2-[(3R)-4-methyl-3-{methyl[(2S,3S)-3-methyl-2-({[(2R)-1-methylpiperidin-2-yl]carbonyl}amino)pentanoyl]amino}pentyl]-1,3-thiazol-4-yl}carbonyl)amino]-5-phenylpentanoate 
• 1174764-13-6 (2S,4R)-4-[((R)-2-{3-[methyl-(N-methyl-(R)-pipecolyl-(S)-isoleucyl)-amino]-4-methyl-pentyl}-thiazole-4-carbonyl)-amino]-2-methyl-5-phenyl-pentanoic acid trifluoroacetic acid salt 
• 1207472-58-9 methyl (2S,4R)-4-[((R)-2-{3-[(N-benzyloxycarbonyl-(R)-pipecolyl-(S)-isoleucyl)methylamino]-4-methylpentyl}thiazole-4-carbonyl)amino]-2-methyl-5-phenylpentanoate 
• 1207472-62-5 (S,E)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 4-((tert-butoxycarbonyl)amino)-2-methyl-5-phenylpent-2-enoate 
• 796039-50-4 (1R,2'R,1'''R,3'''S)-{1-[2'-{4''-[1'''-benzyl-4'''-(tert-butyldiphenylsilanyloxy)-3'''-methylbutylcarbamoyl]thiazol-2''-yl}-2'-(tert-butyldiphenylsilanyloxy)ethyl]-2-methylpropyl}carbamic acid benzyl ester 
• 796039-49-1 (1R,2'R,1'''R,3'''S)-{1-[2'-{4''-[1'''-benzyl-4'''-(tert-butyldiphenylsilanyloxy)-3'''-methylbutylcarbamoyl]oxazol-2''-yl}-2'-(tert-butyldiphenylsilanyloxy)ethyl]-2-methylpropyl}carbamic acid benzyl ester 
• 796039-52-6 (1R,2'R,1''R,3''S)-acetic acid 1-{4'-[1''-benzyl-4''-(tert-butyldiphenylsilanyloxy)-3''-methylbutylcarbamoyl]thiazol-2'-yl}-3-benzyloxycarbonylamino-4-methylpentyl ester 
• 796039-51-5 (1R,2'R,1'''R,3'''S)-[1-(2'-{4''-[1'''-benzyl-4'''-(tert-butyldiphenylsilanyloxy)-3'''-methylbutylcarbamoyl]thiazol-2''-yl}-2'-hydroxyethyl)-2-methylpropyl]carbamic acid benzyl ester 
• 796039-55-9 (1R,3R,1''R,3''S)-acetic acid 1-[4'-(1''-benzyl-4''-hydroxy-3''-methylbutylcarbamoyl)thiazol-2'-yl]-3-benzyloxycarbonylamino-4-methylpentyl ester 

Relevant articles and documents

Design, Synthesis, and Cytotoxic Activity of New Tubulysin Analogues

Synthesis of tubulysin analogues, containing an N-methyl substituent on tubuvaline-amide together with the replacement of either the hydrophobic N-terminal N-methyl pipecolic acid (Mep) or at both N- and C- terminal peptides with available heteroaromatic

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The invention relates to bioactive pre-tubulysin derivatives, their preparation and pharmacological use.

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(Chemical Equation Presented) Advanced intermediates and analogues of tubulysins were prepared in a convergent strategy.