35694-66-7Relevant academic research and scientific papers
Ring-Opening Functionalization of Simple gem-Difluorocyclopropanes by Single-Electron Oxidants
Goto, Toshihito,Kawasaki-Takasuka, Tomoko,Yamazaki, Takashi
, p. 9509 - 9518 (2019)
It was reported for the first time that single-electron oxidants such as CAN or K2S2O8 affected facile ring opening of simple gem-difluorocyclopropanes to afford 1,3-dibromo-2,2-difluoropropanes in good yields by the action of KBr, and the appropriate choice of conditions allowed to incorporate not only second halogen atoms but also hydroxy or acetamido groups at the C1 position in the difluoropropane structures in a regiospecific fashion after initiation of the reaction by the introduction of the first bromine atom at the C3 position. ?
Palladium-catalyzed allylic alkylation dearomatization of β-naphthols and indoles withgem-difluorinated cyclopropanes
Fu, Zhiyuan,Zhu, Jianping,Guo, Songjin,Lin, Aijun
supporting information, p. 1262 - 1265 (2021/02/09)
A palladium-catalyzed allylic alkylation dearomatization of β-naphthols and indoles withgem-difluorinated cyclopropanes has been developed. This reaction provided an efficient route to access 2-fluoroallylic β-naphthalenones and indolenines bearing quaternary carbon centers in good yields with highZ-selectivityviaC-C bond activation, C-F bond cleavage and the dearomatization process, benefiting from the wide substrate scope and good functional group tolerance. Moreover, 2-fluoroallylic furanoindoline and pyrroloindolines were achieved in good efficiencyviacascade allylic alkylation, dearomatization and cyclization processes in the presence of Et3B.
Conversion between difluorocarbene and difluoromethylene ylide
Zheng, Jian,Lin, Jin-Hong,Cai, Ji,Xiao, Ji-Chang
supporting information, p. 15261 - 15266 (2013/11/06)
The interconversion between difluoromethylene ylide and difluorocarbene is described. The difluoromethylene ylide precursor, Ph3P +CF2CO2-, could be turned into an efficient difluorocarbene reagent, w
