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N,N-diethyl-1,1,1-trifluoromethanesulfonamide, also known as Fentanyl, is a potent synthetic opioid analgesic with a rapid onset and short duration of action. It is structurally related to the plant opium poppy and is 50 to 100 times more potent than morphine. Fentanyl is primarily used for the management of acute and chronic pain, as well as for anesthesia during surgical procedures. Due to its high potency, it is also used in veterinary medicine for large animals. However, it has a high potential for abuse and addiction, and its misuse has led to a significant number of overdose deaths. The chemical structure of N,N-diethyl-1,1,1-trifluoromethanesulfonamide consists of a trifluoromethylsulfonamide group attached to a piperidine ring, with two ethyl groups on the nitrogen atoms.

357-39-1

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357-39-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 357-39-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,5 and 7 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 357-39:
(5*3)+(4*5)+(3*7)+(2*3)+(1*9)=71
71 % 10 = 1
So 357-39-1 is a valid CAS Registry Number.

357-39-1Downstream Products

357-39-1Relevant academic research and scientific papers

Hexaalkylguanidinium trifluoromethanesulfonates - A general synthesis from tetraalkylureas and triflic anhydride, and properties as ionic liquids

Kunkel, Helene,Maas, Gerhard

, p. 3746 - 3757 (2008/03/18)

More than thirty hexaalkylguanidinium trifluoromethanesulfonates 12 were prepared from N,N-diethyl-N′,N′-dimethylurea, N,N-dibutyl-N′, N′-diethylurea, or tetrabutylurea, triflic anhydride, and a dialkylamine or cyclic sec-amine in two steps. The combination of the urea and triflic anhydride first yields a bis(tetraalkylamidinio)ether bis(triflate) 10, which is then converted into a salt 12 by reaction with the amine component. The reaction sequence can also be carried out as a one-pot procedure. Eighteen of the prepared guanidinium triflates 12 constitute room-temperature ionic liquids, which were characterized for their melting point, glass transition temperature, viscosity, and refractive index. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.

Formation of sulfinate esters in the synthesis of triflates

Netscher, Thomas,Bohrer, Patrick

, p. 8359 - 8362 (2007/10/03)

On standard treatment of sterically congested alcohols and phenols with triflic anhydride in the presence of amines, trifluoromethanesulfinyl esters were unexpectedly found. Depending on the reaction conditions and the structures of both hydroxy compound and base, esterified products (yields 5% to 99%) containing 0% to 89% (!) of sulfinates were obtained. The mechanisms of these reactions are discussed. The results of the present study indicate how to avoid unwanted sulfinate formation in triflate synthesis.

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