35710-18-0Relevant academic research and scientific papers
A simple synthesis of 2-substituted-4H-3,1-benzoxazin-4-ones by palladium-catalyzed cyclocarbonylation of o-iodoanilines with acid chlorides
Larksarp, Chitchamai,Alper, Howard
, p. 1619 - 1622 (1999)
(matrix presented). One-pot reaction of o-iodoanilines with acid chlorides and carbon monoxide, in the presence of a palladium catalyst and diisopropylethylamine, regioselectively affords 2-substituted-4H-3,1-benzoxazin-4-ones in good to excellent yields. The reaction is believed to proceed via in situ amide formation from an o-iodoaniline and an acid chloride, followed by oxidative addition to Pd(0), CO insertion, and intramolecular cyclization to form the 2-substituted-4H-3,1-benzoxazin-4-one derivatives.
