357193-27-2

Upstream product

• 358-23-6 trifluoromethylsulfonic anhydride 
• 527-54-8 3,4,5-trimethylphenol 

Downstream Products

• 357193-13-6 4,4,5,5-tetramethyl-2-(3,4,5-trimethylphenyl)[1,3,2]dioxaborolane 
• 52414-95-6 3,4,5-trimethyl-1-nitrobenzene 
• 1404232-32-1 1,2-bis(3,4,5-trimethylphenyl)ethyne 
• 357193-21-6 tert-butyl 5-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-3-[(1S)-2-{[(2,4-dinitrophenyl)sulfonyl]amino}-1-methylethyl]-2-(3,4,5-trimethylphenyl)-1H-indole-1-carboxylate 
• 357193-23-8 tert-butyl 5-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-3-[(1S)-1-methyl-2-[(2-pyridin-4-ylethyl)amino]ethyl]-2-(3,4,5-trimethylphenyl)-1H-indole-1-carboxylate 
• 357193-15-8 tert-butyl 5-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-3-[(1S)-2-(benzyloxy)-1-methylethyl]-2-(3,4,5-trimethylphenyl)-1H-indole-1-carboxylate 
• 357193-17-0 tert-butyl 5-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-3-[(1S)-2-azido-1-methylethyl]-2-(3,4,5-trimethylphenyl)-1H-indole-1-carboxylate 
• 357193-19-2 tert-butyl 5-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-3-[(1S)-2-amino-1-methylethyl]-2-(3,4,5-trimethylphenyl)-1H-indole-1-carboxylate 
• 357193-16-9 tert-butyl 5-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-3-[(1S)-2-hydroxy-1-methylethyl]-2-(3,4,5-trimethylphenyl)-1H-indole-1-carboxylate 
• 357193-14-7 5-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-3-[(1S)-2-(benzyloxy)-1-methylethyl]-2-(3,4,5-trimethylphenyl)-1H-indole 

Relevant academic research and scientific papers

A Modular Synthetic Approach to Monocyclic 1,4-Azaborines

A simple and general method for the synthesis of a wide range of monocyclic 1,4-azaborines, including the first examples containing B heteroatoms is described. Post-heterocycle-formation olefin isomerization was employed as a key strategy. This new synthetic method provides fundamental insight into the resonance stabilization and photophysical properties of 1,4-azaborines.

PYRIMIDONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE

The present invention relates to a compound having the general formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease, in particular influenza.

Helical atropisomers of strained phenanthrenes by photochemistry of aromatic Pauson-Khand cycloadducts

Norbornene and norbornadiene Pauson-Khand adducts of bis(3,5- dimethylphenyl)acetylene and bis(3,4,5-trimethylphenyl)acetylene were prepared. These compounds were subjected to a photochemical 6π-electrocyclic oxidative aromatization reaction to give the corresponding phenanthrene compounds in satisfactory yield in the case of norbornene derivatives. The helical twist imposed by the methyl groups at the 3- and 5-positions on the aromatic rings led to two atropisomers as a result of the non-planar helical phenanthrene structure. The molecular structures and conformational stabilities of these atropisomers were examined by X-ray crystallography and variable temperature NMR studies. Norbornene and norbornadiene Pauson-Khand adducts of bis(3,5-dimethylphenyl)acetylene and bis(3,4,5-trimethylphenyl)acetylene were subjected to a photochemical 6π-electrocyclic oxidative aromatization reaction to give the corresponding phenanthrene compounds. The helical twist imposed by the methyl groups at the 3- and 5-positions on the aromatic rings led to two atropisomers as a result of the non-planar helical phenanthrene structure.

Quinolones as gonadotropin releasing hormone (GnRH) antagonists: Simultaneous optimization of the C(3)-aryl and C(6)-substituents

A series of 3-arylquinolones was prepared and evaluated for their ability to act as gonadotropin releasing hormone (GnRH) antagonists. A variety of substitution patterns of the 3-aryl substituent are described. The 3,4,5-trimethylphenyl substituent (23h) was found to be optimal. (C) 2000 Elsevier Science Ltd. All rights reserved.