357194-27-5Relevant articles and documents
Tri- and tetrasubstituted α-fluorocyclohexanones with enantiomeric excesses in the range of 97-100%
Solladie-Cavallo, Arlette,Jierry, Loc,Bouerat, Laetitia,Taillasson, Philippe
, p. 883 - 891 (2007/10/03)
The α-fluorinated trisubstituted ketones (2S,5R)-(-)-7-Ia, (2R,5R)-(+)-7-IIe, (2S,5R)-(-)-8-Ia and (2R,5R)-(+)-8-IIe were synthesised from (+)-dihydrocarvone (99% (R)-configuration at C-5) and fully characterised. α-Fluorinated tetrasubstituted ketones (-)-9-Ia, (+)-9-Ia, (+)-9-IIa and (+)-10-Ia having e.e.s of ≥97% were synthesised as racemates from 3-methyl cyclo-hexenone then resolved into the pure enantiomers using chiral HPLC and fully characterised.