357205-17-5

Basic information

• Product Name: Carbamic acid, [(1R)-2-hydroxy-1-(mercaptomethyl)ethyl]-, 1,1-dimethylethyl
• Synonyms: Carbamic acid, [(1R)-2-hydroxy-1-(mercaptomethyl)ethyl]-, 1,1-dimethylethyl
• CAS NO: 357205-17-5
• Molecular Formula: C₈H₁₇NO₃S
• Molecular Weight: 207.29048
• Product Categories: N-BOC
• Mol File: 357205-17-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Carbamic acid, [(1R)-2-hydroxy-1-(mercaptomethyl)ethyl]-, 1,1-dimethylethyl(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1R)-2-hydroxy-1-(mercaptomethyl)ethyl]-, 1,1-dimethylethyl(357205-17-5)
• EPA Substance Registry System: Carbamic acid, [(1R)-2-hydroxy-1-(mercaptomethyl)ethyl]-, 1,1-dimethylethyl(357205-17-5)

Safety Data

• Hazardous Substances Data: 357205-17-5(Hazardous Substances Data)

Upstream product

• 126645-38-3 N-<(tert-butyloxy)carbonyl>-S-acetyl-L-cysteine methyl ester 
• 187035-34-3 (S)-2-tert-butoxycarbonylamino-3-methanesulfonyloxypropionic acid methyl ester 
• 2766-43-0 N-tert-butyloxycarbonyl-L-serine methyl ester 
• 172749-96-1 N-[(tert-butoxy)carbonyl]-L-cysteine methyl ester 

Downstream Products

• 79409-99-7 N-(tert-butoxycarbonyl)-S-oxo-S-(cyanobenzyl)-L-cysteinol 
• 79409-99-7 N-(tert-butoxycarbonyl)-S-oxo-S-(cyanobenzyl)-L-cysteinol 

Relevant articles and documents

L-cysteine, a versatile source of sulfenic acids. Synthesis of enantiopure alliin analogues

(Chemical Equation Presented) L-Cysteine is a stimulating starting product for the generation of transient sulfenic acids, such as 4, 6, 9, and 15, which add to suitable acceptors, allowing formation of sulfoxides showing a biologically active residue. These sulfoxides are easily isolated in enantiomerically pure form. For instance, N-(tert-butoxycarbonyl)-L-cysteine methyl ester (1a) furnished in few steps sulfenic acid 9a, which was readily converted into (R,SS)-(2-tert-butoxycarbonylamino-2-methoxycarbonyl- ethylsulfinyl)ethene (22), the methyl ester of Boc-protected nor-alliin. Moreover, the addition of 9a to 2-methyl-1-buten-3-yne has led to a sulfur epimeric and separable mixture of (CR)-2-(2-tert-butoxycarbonylamino-2- methoxycarbonyl-ethylsulfinyl)-3-methyl-buta-1,3-dienes 10a and 11a, still possessing a "masked" sulfenic acid function, producible from their cysteine moieties once the dienes have been converted into the desired derivatives.

SULFONAMIDES AS HIV PROTEASE INHIBITORS

Compounds of Formula I are disclosed: wherein L, A, R1, R2, R3A, R3B, R4A, R4B, R5, R6 and R7 are defined herein. The compounds encompassed by Formula I include compounds which are HIV protease inhibitors and other compounds which can be metabolized in vivo to HW protease inhibitors. The compounds and their pharmaceutically acceptable salts are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines

Synthesis and Ring-Opening Reactions of Functionalized Sultines. A New Approach to Sparsomycin

An efficient route leading to the functionalized five-membered cyclic sulfinate esters (γ-sultines) 14a,b and 21a,b is described on the basis of the reaction of the N-protected cystinol derivatives 11 and 20, respectively, with N-chlorosuccinimide (NCS) a