357205-58-4Relevant academic research and scientific papers
Synthesis of oxazolidinyl azacycles via ring-closing olefin metathesis: A practical entry to the synthesis of deoxy-azasugars and hydroxypyrrolizidines
Subramanian, Thangaiah,Lin, Chang-Ching,Lin, Chun-Cheng
, p. 4079 - 4082 (2001)
Starting with D- and L-serines, an expedient method for the preparation of oxazolidinyl piperidines, azepenes and azacyclooctenes was illustrated as a route to various deoxy-azasugars and hydroxypyrrolizidines. The ring-closing olefin metathesis of oxazolidinyl di-olefins was used as a key-step to construct the azacycles. Consecutive epoxidation, hydrolysis and transannulation of oxazolidinyl azacyclooctene led to hydroxypyrrolizidines.
