357290-69-8Relevant articles and documents
Studies in aza-Claisen rearrangement: Synthesis of dimedone-annelated unusual heterocycles
Majumdar,Samanta
, p. 4955 - 4958 (2007/10/03)
A number of 3-N-(4′-aryloxybut-2′-ynyl)N-methyl amino-5,5-dimethyl cyclohex-2-enones are synthesized in 62-65% yield by refluxing 3-chloro-5,5-dimethyl cyclohex-2-enone with a number of 4-aryloxy-4-chlorobut-2-ynes in ethanol for 4 h. The amines are then
Studies in sigmatropic rearrangement: Synthesis of 4-aryloxy-methylene-1,7-dimethyl-1,2,3-trihydropyridino-[3,2-c]pyran-5-ones
Majumdar,Ghosh
, p. 1589 - 1592 (2007/10/03)
A number of 4-[N-4′-aryloxy but-2-ynyl N-methyl amino-6-methyl pyran-2-ones (4a-g) have been prepared in excellent yields from N-(1-aryloxy-but-2-ynyl)-N-methyl amine (3) and 4-tosyloxy-6-methyl-pyran-2-one (2). Thermal rearrangement of compounds 4(a-g) gave 4-aryloxy-methyl-1,7-dimethyl-1,2-dihydropyridino-[3,2-c] pyran-5-ones (6) and/or 4-aryloxymethylene-1,7-dimethyl-1,2,3-trihydropyridino-[3,2-c] pyran-5-ones (5).
Synthesis of bioactive heterocycles: Sigmatropic rearrangements of 1,3-dimethyl-6-[methyl(4-aryloxybut-2-ynyl)amino]pyrimidine-2,4(1H,3H)-diones
Majumdar,Bhattacharyya
, p. 1568 - 1572 (2007/10/03)
A number of 1,3-dimethyl-6-[methyl (4-aryloxybut-2-ynyl)amino]pyrimidine-2,4(1H,3H)-diones 4a-i were synthesised in 69 to 80% yields by the reaction of 6-chloro-1,3-dimethyluracil (6-chloro-1,3-dimethylpyrimidine-2,4(1H, 3H)-diones) and 1-aryloxy-4-N-methylaminobut-2-yne in refluxing ethanol for 12 hours. The tertiary amines 4a-i were then heated in refluxing 1,2-dichlorobenzene for 17 hours to give 5-[(E)-aryloxymethylidene]-1,3,8-trimethyl-5,6,7,8-tetrahydropyrido[2,3-d] pyrimidine-2,4(1H,3H)- diones 5a-i in 55 to 75% yields.
