357436-25-0

Basic information

• Product Name: (3xi,5alpha,13alpha)-taxa-4(20),11-diene-5,13-diol
• CAS NO: 357436-25-0
• Molecular Formula: C₂₀H₃₂O₂
• Molecular Weight: 304.4669
• Mol File: 357436-25-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 427.4°C at 760 mmHg
• Flash Point: 189.1°C
• Density: 1.05g/cm³
• Vapor Pressure: 4.25E-09mmHg at 25°C
• Refractive Index: 1.542
• CAS DataBase Reference: (3xi,5alpha,13alpha)-taxa-4(20),11-diene-5,13-diol(CAS DataBase Reference)
• NIST Chemistry Reference: (3xi,5alpha,13alpha)-taxa-4(20),11-diene-5,13-diol(357436-25-0)
• EPA Substance Registry System: (3xi,5alpha,13alpha)-taxa-4(20),11-diene-5,13-diol(357436-25-0)

Safety Data

• Hazardous Substances Data: 357436-25-0(Hazardous Substances Data)

Upstream product

• 1581285-71-3 5α-acetoxytaxa-4(20),11(12)-dien-13-one 
• 163594-75-0 taxadiene 
• 1042946-01-9 5α,13α-bis[diethyl(isopropyl)silyloxy]-taxa-4(20),11(12)-diene 
• 1042945-91-4 5α,13α-bis(triethylsilyloxy)-taxa-4(20),11(12)-diene 

Relevant articles and documents

Studies on Taxol biosynthesis: preparation of taxadiene-diol and triol derivatives by deoxygenation of taxusin

The putative Taxol biosynthesis metabolites, taxa-4(20),11(12)-diene-5α,13α-diol (7), taxa-4(20),11(12)-diene-5α,9α,13α-triol (9), and taxa-4(20),11(12)-diene-5α,10β,13α-triol (10), have been prepared by Barton deoxygenation of the C-9 and C10-hydroxyl groups of protected derivatives of taxusin, a major taxoid metabolite isolated from Yew heart wood. The synthetic protocol devised is amenable for the preparation of isotopically labeled congeners that will be useful to probe further intermediate steps in the biosynthesis of Taxol.