357436-78-3

Upstream product

• 1775-95-7 2-amino-5-nitrobenzophenone 
• 313499-48-8 N-(2-benzoyl-4-nitrophenyl)trifluoroacetamide 

Downstream Products

• 366456-90-8 N-[3-benzoyl-4-[2-(4-nitrophenyl)acetylamino]phenyl]-N^α-tert-butyloxycarbonyl-S-tritylcysteinamide 
• 1027988-91-5 N-[3-benzoyl-4-(4-methylphenylmethansulfonylamino)phenyl]-N^α-tert-butyloxycarbonyl-S-tritylcysteinamide 
• 366456-91-9 N-[3-benzoyl-4-(phenylmethansulfonylamino)phenyl]-N^α-tert-butyloxycarbonyl-S-tritylcysteinamide 
• 366456-89-5 N-[4-amino-3-benzoylphenyl]-N^α-tert-butyloxycarbonyl-S-tritylcysteinamide 
• 866835-68-9 (E)-(RS)-N-[2-benzoyl-4-{3-[5-(4-nitrophenyl)-2-furyl]acryloyl-amino}phenyl]-N-tert-butoxycarbony-4-trifluoromethylphenylalanine amide 
• 866835-66-7 (E)-(R)-N-[2-benzoyl-4-{3-[5-(4-nitrophenyl)-2-furyl]acryloyl-amino}phenyl]-N-tert-butoxycarbonyphenylalanine amide 
• 866835-64-5 (E)-(S)-N-[2-benzoyl-4-{3-[5-(4-nitrophenyl)-2-furyl]acryloyl-amino}phenyl]-N-tert-butoxycarbonyphenylalanine amide 
• 605636-80-4 (E)-N-(4-amino-3-benzoylphenyl)-3-[5-(4-nitrophenyl)-2-furyl]acrylic acid amide 

Relevant academic research and scientific papers

Non-thiol farnesyltransferase inhibitors: N-(4-aminoacylamino-3- benzoylphenyl)-3-[5-(4-nitrophenyl)-2 furyl]acrylic acid amides and their antimalarial activity

Water solubility was previously found to be essential for in vivo-antimalarial activity of a novel type of benzophenone-based farnesyltransferase inhibitors. Introduction of a α-amino group into the phenylacetic acid substructure provided more soluble compounds with high farnesyltransferase inhibitory activity. The in vitro-antimalarial activity was detrimentally influenced by this structural modification.

Structure-activity relationships of novel anti-malarial agents. Part 6: N-(4-arylpropionylamino-3-benzoylphenyl)-[5-(4-nitrophenyl)-2-furyl]acrylic acid amides

We have demonstrated that the p-trifluoromethylphenylpropionylamino residue at the 2-position of the core structure leads to an active benzophenone-type anti-malarial agent. The attempt to improve water solubility by introduction of an amino group into th

Structure-activity relationships of novel anti-malarial agents. Part 3: N-(4-Acylamino-3-benzoylphenyl)-4-propoxycinnamic acid amides

We have described 5-(4-propoxycinnamoylamino)-2-(4-tolylacetylamino)benzophenone 6e as a novel lead for anti-malarial agents. Anti-malarial activity of these 5-(4-propoxycinnamoylamino)benzophenones proved to be quite sensitive against variations of the a

Non-thiol farnesyltransferase inhibitors: N-(4-Acylamino-3-benzoylphenyl)-4-nitrocinnamic acid amides

We have developed a 4-nitrocinnamoyl substituted benzophenone as a novel non-thiol farnesyltransferase inhibitor. Replacement of the p-tolyl moiety of our initial lead structure by different para and ortho substituted phenyl residues as well as by 1-naphthyl resulted in derivatives with considerably enhanced activity displaying IC50 values between 42 and 52 nM. These compounds represent novel, readily accessible non-thiol farnesyltransferase inhibitors being more active than the corresponding thiol-containing analogues. Copyright

Synthesis, molecular modeling, and structure - Activity relationship of benzophenone-based CAAX-peptidomimetic farnesyltransferase inhibitors

Because of the involvement of farnesylated proteins in oncogenesis, inhibition of the protein-modifying enzyme farnesyltransferase is considered a major emerging strategy in cancer therapy. Here, we describe the structure - activity relationship of a nove