866835-68-9

Upstream product

• 167496-29-9 N-t-BOC-4-(trifluoromethyl)phenylalanine 
• 605636-80-4 (E)-N-(4-amino-3-benzoylphenyl)-3-[5-(4-nitrophenyl)-2-furyl]acrylic acid amide 
• 808170-24-3 N-[3-benzoyl-4-(trifluoroacetylamino)phenyl]-3-[5-(4-nitrophenyl)-2-furyl]acrylic acid amide 
• 1775-95-7 2-amino-5-nitrobenzophenone 
• 313499-48-8 N-(2-benzoyl-4-nitrophenyl)trifluoroacetamide 
• 357436-78-3 N-(4-amino-2-benzoylphenyl)-trifluoroacetic acid amide 

Relevant academic research and scientific papers

2-(Aminoacylamino)benzophenones: Farnesyltransferase inhibition and antimalarial activity

The use of amino acids as acyl substitutents at the 2-amino group of our benzophenone core structure yielded compounds with mainly good to moderate farnesyltransferase inhibitory and moderate antimalarial activity. However, these farnesyltransferase inhibitors display some degree of selectivity towards malarial parasites since there was no cytotoxic activity observed at 70-80 μM.

Structure-activity relationships of novel anti-malarial agents. Part 6: N-(4-arylpropionylamino-3-benzoylphenyl)-[5-(4-nitrophenyl)-2-furyl]acrylic acid amides

We have demonstrated that the p-trifluoromethylphenylpropionylamino residue at the 2-position of the core structure leads to an active benzophenone-type anti-malarial agent. The attempt to improve water solubility by introduction of an amino group into th