35749-06-5

Upstream product

• 25887-81-4 bis(p-nitrophenyl)sulfite 
• 33237-32-0 N-benzyloxycarbonyl-L-alanyl-L-phenylalanyl-L-proline 
• 147-85-3 L-proline 
• 3235-15-2 N-benzyloxycarbonyl-L-alanyl-L-phenylalanyl hydrazide 

Downstream Products

• 36477-14-2 5-benzyl-10b-methoxy-2-methyl-3,6-dioxo-octahydro-imidazo[1,2-a]pyrrolo[2,1-c]pyrazine-1-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Structural Studies of Azacyclos derived from Linear Tripeptides

N-Benzyloxycarbonyl-L-alanyl-L-phenylalanyl-L-proline p-nitrophenyl ester (4) and its N-p-bromobenzyloxycarbonyl analogue (2) each cyclize in alkaline aqueous medium to give a tricyclic system containing a free hydroxy-group derived from intramolecular addition of NH to amide carbonyl.Both the five-membered rings of the tricyclic system assume an envelope conformation.In the six-membered ring only the carbon atom bearing the cyclolic hydroxy-group is out of the plane of the other ring atoms.The benzylic side-chain of the phenylalanine residue adopts an extended conformation in both azacyclols.The crystal and molecular structures and spectral data for the tricyclic compounds (3) and (5) are reported.