35753-93-6Relevant academic research and scientific papers
PIPERAZINYL DERIVATIVES AND METHODS OF TREATING CENTRAL NERVOUS SYSTEM AILMENTS RELATING TO THE 5-HT2 RECEPTOR SYSTEM
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, (2008/06/13)
Piperazinyl derivatives of the general formula I STR1 wherein R. sup.1 represents substituted phenyl, 1-or 2-diazanaphthyl, azadiazanaphtyl or diazanaphtyl groups; n is 1, 2, 3 or 4; X is--O--or STR2 wherein R. sup.2 is hydrogen, C 1-6-alkyl or C 3-8-cycloalkyl; Y is =O or =S or =NZ wherein Z is hydrogen, C. sub. 1-6-alkyl or--CN and R 3 is selected from a group consisting of various structures have been found to exhibit high affinity for various receptor subtypes including the 5-HT 2 receptor, the 5-HT 1A receptor, the alpha 1 receptor the dopamine receptor or a combination of these and may therefore be useful for treating CNS system, cardiovascular system and gastrointestinal disorders.
Synthesis and Investigation of Effects of 2-amino>phenoxy>-2-methylpropionic Acids on the Affinity of Hemoglobin for Oxygen: Structure-Activity Relationships
Lalezari, Iraj,Lalezari, Parviz
, p. 2352 - 2357 (2007/10/02)
A series of 2-carbonyl>amino>phenoxy>-2-methylpropionic acids and other substituted phenoxyacetic acids were synthesized and tested for their ability to reduce the affinity of hemoglobin for oxygen. 2-4-(3,4,5-Trichloro
