35755-43-2

Upstream product

• 25917-49-1 1-(4-chlorophenyl)-2-(p-tolylsulfonyloxy)ethanone 
• 62-53-3 aniline 
• 99-91-2 para-chloroacetophenone 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 118985-12-9 p-chlorophenacyl m-nitrobenzenesulphonate 
• 118985-11-8 p-chlorophenacyl p-chlorobenzenesulphonate 
• 115400-12-9 p-chlorophenacyl benzenesulphonate 
• 64-17-5 ethanol 

Downstream Products

• 1211-35-4 2-(4-chlorophenyl)-1H-indole 
• 3237-59-0 3-(4-chlorophenyl)quinoline 
• 70391-37-6 (4-chlorophenyl)(quinolin-2-yl)methanone 
• 1401615-92-6 (4-chlorophenyl)(1-(phenylamino)cyclopropyl)methanone 
• 1609985-43-4 (Z)-(5-(4-chlorobenzylidene)-1,2-diphenyl-2,5-dihydro-1H-pyrazole-3,4-diyl)bis((4-chlorophenyl)methanone) 
• 1459738-75-0 2-(4-chlorophenyl)-N-phenylimidazo[1,2-a]pyridin-3-amine 
• 92425-84-8 2-anilino-1-(4-chloro-phenyl)-propan-1-one 
• 1127405-07-5 1-(4-chloro-phenyl)-2-(morpholin-4-yl)ethane-1,2-dione 

Relevant academic research and scientific papers

Synthesis of (Z)-nitroalkene derivatives through oxidative dehydrogenation coupling of α-aminocarbonyl compounds with nitromethane by copper catalysis

A novel copper-catalyzed cross-dehydrogenative coupling reaction of α-amino carbonyl compounds with nitromethane to synthesis of (Z)-nitroalkene derivatives has been established. (Z)-Nitroalkene derivatives are achieved through the cleavage of sp3 CsbndH bonds and formation of CsbndC double bond, with mild reaction conditions and excellent stereoselectivity.

Copper-catalyzed oxidative cross-coupling of α-aminocarbonyl compounds with primary amines toward 2-oxo-acetamidines

A general and mild method for the construction of a carbon-nitrogen bond via copper-catalyzed oxidative cross-coupling of amines with α-aminocarbonyl compounds was achieved. Amines, either aliphatic primary amines, aromatic primary amines or secondary amines can be used as the starting materials. When R2 was different from R3, two isomers would be observed. Therefore, this reaction system has a broad substrate scope and provides a facile pathway for the synthesis of 2-oxo-acetamidines.

New efficient synthesis of 1,4-benzodiazepin-5-ones by catalytic aza-Wittig reaction

1,4-Benzodiazepin-5-ones were synthesized in 71-89% yields from 2-isocyanato-N-(2-oxoalkyl)benzamides via a new catalytic intramolecular aza-Wittig reaction. Starting from easily accessible phthalic anhydride and α-arylamino ketones, the corresponding 2-{[(2-oxoalkyl)amino]carbonyl}benzoic acids underwent sequential formation of the acid azide and Curtis rearrangement to give 2-isocyanato-N-(2-oxoalkyl)benzamides that were reacted directly to give the final 2,4-diaryl-3,4-dihydro-5H-1,4-benzodiazepin-5-ones and 4-aryl-2-tert-butyl-3,4-dihydro-5H-1,4-benzodiazepin-5-ones.

One-Pot Metal-Free Cascade Synthesis of 2-(Perfluoroalkyl)pyrroles

An efficient synthesis of 2-(perfluoroalkyl)pyrroles that employs a sequential one-pot three-component reaction between substituted ω-bromoacetophenones, anilines, and methyl perfluoroalk-2-ynoates has been developed. This transition-metal-free cascade pr

Synthesis, antibacterial activity and binding mode analysis of some novel 1,4-diaryl imidazole thiones

A novel series of fifteen diaryl imidazole thiones 2a-o was synthesized by reacting the corresponding 1-(aryl)-2-(arylamino)-ethanones 1 with ammonium thiocyanate. The compounds have been characterized on the basis of elemental analysis and spectral data.

Microwave-assisted, solvent-free Bischler indole synthesis

The solid-state reaction between anilines and phenacyl bromides in the presence of an equimolecular amount of sodium bicarbonate gives N-phenacylanilines. Microwave irradiation of mixtures of these compounds with anilinium bromides at 540 W for 45-60 s provides a mild, general, and environmentally friendly method for the synthesis of 2-arylindoles in 50-56% overall yields. A one-pot variation of the method, involving irradiation of 2:1 mixtures of anilines and phenacyl bromides, was also developed, allowing a simplified experimental procedure and leading to improved yields (52-75%). Georg Thieme Verlag Stuttgart.

On the reaction of 2-phenylaminothiazoline with α-halogenoketones

It was established that the alkylation of 2-phenylaminothiazoline with substituted phenacyl bromides proceeds at the exocyclic nitrogen atom with the formation of 5-aryl-7-phenyl-2,3-dihydroimidazo[2,1-b]thiazolium bromides. In order to confirm the struct

PREPARATION OF NEW THIOHYDROXAMIC ACID DERIVATIVES: SYNTHESIS OF SUBSTITUTED 1-HYDROXY-1,2-DIHYDROIMIDAZOLE-2-THIONES

A general method for the synthesis of the title compounds is reported.The N-phenacylarylamines (11), prepared from the corresponding phenacyl bromides (9) and arylamines (10), give the thiono (or dithio) carbamates (12) on treatment with phenoxythionocarb

A convenient synthesis of α-anilinoacetophenones using hypervalent iodine

Hypervalent iodine oxidation of acetophenones (1) with benzene, followed by treatment with appropriate aniline, provides a new, convenient and useful route to the synthesis of α-anilinoacetophenones (3a-h).

Nucleophilic Substitution Reactions of Phenacyl Benzenesulphonates with Anilines in Methanol-Acetonitrile Mixtures

The nucleophilic substitution reactions of phenacyl benzenesulphonates with anilines in methanol-acetonitrile have been studied.A stronger nucleophile was found to cause less bond cleavage, while a better leaving group led to less bond formation, in compl