357625-82-2

Upstream product

• 357625-78-6 (2S,3R)-3-((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-2,3-dihydroxy-propionic acid methyl ester 
• 1053628-43-5 (2S,3R)-3-((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,3-dihydroxy-2-hydroxymethyl-propionic acid methyl ester 
• 357625-77-5 2-[(S)-((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-acrylic acid methyl ester 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 81028-12-8 (4S,5R)-4-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane-5-carboxaldehyde 
• 357625-76-4 (2S,3S)-3-((4R,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-oxirane-2-carboxylic acid methyl ester 

Downstream Products

• 1197205-98-3 C₂₃H₃₇IO₅Si 

Relevant academic research and scientific papers

A flexible common approach to α-substituted serines and alanines: Diastereoconvergent syntheses of sphingofungins E and F

A flexible common approach for the asymmetric syntheses of sphingofungins E and F is reported, with efficient use of both diastereomers of the Baylis-Hillman adduct in a stereoconvergent manner. Pronounced steric effects of the 2-substituents in diastereo

The first total synthesis of sphingofungin E and the determination of its stereochemistry

The total synthesis of sphingofungin E has been realized for the first time and its absolute configurations were established. Starting from L-(+)-tartaric acid, our synthesis featured substrate-controlled asymmetric dihydroxylation, regiospecific epoxide formation and Hatakeyama reaction to construct the contiguous chiral centers in the target molecule.