357637-72-0Relevant academic research and scientific papers
K2S2O8-catalyzed highly regioselective amidoalkylation of diverse N-heteroaromatics in water under visible light irradiation
Chen, Zhi,Li, Jianjun,Ren, Quanlei,Song, Shengjie,Wang, Chaodong,Xu, Ning,Zhou, Jiadi
supporting information, p. 5753 - 5758 (2021/08/23)
A K2S2O8-catalyzed versatile C(sp2)-C(sp3) bond formation with N-heteroaromatics and γ-lactams/amides was developed. Quinoxalin-2(1H)-one, quinoline, isoquinoline, phthalazine, and benzothiazole reacted with γ-lactams/amides to give the corresponding C(sp2)-H amidoalkylation products in moderate to good yields with high regioselectivity. This visible-light-induced photocatalyst-free reaction was conducted in H2O at ambient temperature, which comply with the principles of "green chemistry". The new K2S2O8 catalytic mechanism was investigated with control experiments.
Synthesis and SAR of novel imidazoquinoxaline-based Lck inhibitors: Improvement of cell potency
Chen, Ping,Iwanowicz, Edwin J.,Norris, Derek,Gu, Henry H.,Lin, James,Moquin, Robert V.,Das, Jagabandhu,Wityak, John,Spergel, Steven H.,De Fex, Henry,Pang, Suhong,Pitt, Sydney,Shen, Ding Ren,Schieven, Gary L.,Barrish, Joel C.
, p. 3153 - 3156 (2007/10/03)
A series of anilino(imidazoquinoxaline) analogues bearing solubilizing side chains at the 6- and 7-positions of the fused phenyl ring has been prepared and evaluated for inhibition against Lck enzyme and of T-cell proliferation. Significant improvement of the cellular activity was achieved over the initial lead, compound 2.
