35790-47-7Relevant academic research and scientific papers
Protein labeling approach to improve lysosomal targeting and efficacy of antibody-drug conjugates
Cai, Xiaoqing,Cheng, Yaping,Da, Yifan,Guo, Guoying,Han, Ying,Jiang, Xianxing,Li, Yan,Wang, Xin,Xiong, Jiale,Yu, Mingjia
, p. 3229 - 3233 (2020)
An anti-EGFR nanobody was labeled at the C-terminus with a lysosome-sorting NPGY (Asn-Pro-Gly-Tyr) motifviasortase-mediated ligation to enhance the engagement of the clathrin-mediated endocytosis. The synergistic effects of NPGY motif and nona-arginine peptide were found to induce robust internalization and lysosomal trafficking, which in turn improved anti-tumor activity of an antibody-drug conjugate.
A new protective agent diphenylmethane (by machine translation)
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Paragraph 0202, (2018/05/03)
Functional group protected compound insoluble solid or not, after the separation, purification facilitating to develop a protecting group. General formula (1) (In the formula, Y is a - OR19 (Wherein R19 Is a hydrogen atom or an active ester-type protecting group), - NHR20 (Here, R20 Represents a hydrogen atom, a linear or branched alkyl group of 1 - 6 carbon atoms, or an aralkyl group such as a, R1 - R10 One of the few (2) 1 To both of the formula Represents a group represented by, the remainder is a hydrogen atom, a halogen atom, the carbon number of 1 - 4 carbons or alkoxy of 1 - 4 alkyl group; R11 Straight or branched chain alkylene group of 1 - 16 carbon atoms; X is O or CONR21 (Wherein R21 The number of alkyl groups of 1 - 4 carbon atoms or hydrogen) is shown; (3) The formula A etc. In group shown) The diphenylmethane compound represented. (by machine translation)
