35793-46-5Relevant academic research and scientific papers
Hydrazonyl Radical-Participated Tandem Reaction: A Strategy for the Synthesis of Pyrazoline-Functionalized Oxindoles
Duan, Xiao-Yong,Yang, Xiu-Long,Jia, Pan-Pan,Zhang, Man,Han, Bing
, p. 6022 - 6025 (2015)
An efficient and practical tandem cyclization/addition/cyclization strategy is developed for the initial generated hydrazonyl radicals derived from the oxidation of β,γ-unsaturated hydrazones. By using this protocol, structurally novel pyrazoline-functionalized oxindoles are prepared by the reaction of easily accessible β,γ-unsaturated hydrazones with N-aryl acrylamides under the metal- and solvent-free conditions of DTBP (di-tert-butyl peroxide) via a tandem intra/intermolecular C-N/C-C/C-C bond formation.
Silver-prompted carbonitration of acrylamides for the synthesis of nitrating oxindoles
Wei, Xiao-Hong,Wu, Quan-Xiang,Yang, Shang-Dong
supporting information, p. 1417 - 1421 (2015/06/16)
A silver-prompted carbonitration of alkenes involving concomitant direct C-H functionalization and C-N bond formation to synthesize nitrating oxindoles has been developed. The CR TH2 receptor antagonist skeleton can be obtained from one of the products with further modification.
