358359-75-8Relevant academic research and scientific papers
Synthesis and biological activity of 4′-thio-L-xylofuranosyl nucleosides
Tiwari,Messini,Montgomery,Secrist III
, p. 743 - 746 (2007/10/03)
A series of 4′-thio-L-xylofuranosyl nucleosides were prepared and evaluated as potential anticancer and antiviral agents. The details of a convenient and high-yielding synthesis of the carbohydrate precursor 1-O-acetyl-2,3,5-tri-O-benzyl-4- thio-L-xylofuranose (6) are presented. Proof of structure and configuration at all chiral centers of the nucleosides was obtained by proton and carbon NMR. All target compounds were evaluated in a series of human cancer cell lines in culture and as antiviral agents.
