331819-82-0

Upstream product

• 37439-79-5 2-allyl-3-acetamidophenol 
• 37439-78-4 N-(3-(allyloxy)phenyl)acetamide 
• 340774-75-6 2-allyl-3-methoxyaniline 
• 340774-74-5 acetic acid-(2-allyl-3-methoxy-anilide) 
• 621-42-1 meta-hydroxyacetanilide 
• 57356-31-7 2-(hydroxymethyl)-3-nitrophenol 
• 331819-79-5 2-amino-3-(2-methoxy-6-nitro-phenyl)-propionic acid tert-butyl ester 
• 19689-87-3 (2-methoxy-6-nitrophenyl)methanol 
• 19689-86-2 2-nitro-6-methoxybenzyl bromide 
• 50603-42-4 5-nitro-1,3-benzodioxane 
• 340774-81-4 (S)-3-[2-(2,5-Dimethyl-pyrrol-1-yl)-6-methoxy-phenyl]-2-((R)-2-hydroxy-1-phenyl-ethylamino)-propionic acid methyl ester 
• 340774-79-0 (S)-3-[2-(2,5-Dimethyl-pyrrol-1-yl)-6-methoxy-phenyl]-2-((R)-2-hydroxy-1-phenyl-ethylamino)-propionitrile 
• 340774-82-5 2-tert-butoxycarbonylamino-3-[2-(2,5-dimethyl-pyrrol-1-yl)-6-methoxy-phenyl]-propionic acid methyl ester 
• 340774-77-8 3-[2-(2,5-dimethyl-pyrrol-1-yl)-6-methoxy-phenyl]-propane-1,2-diol 

Downstream Products

• 331819-86-4 (S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-3-methoxy-phenylamino]-3-methyl-butyric acid 
• 331819-84-2 (S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-3-methoxy-phenylamino]-3-methyl-butyric acid benzyl ester 
• 358365-66-9 2-[2-(2-tert-butoxycarbonylamino-3-hydroxy-propyl)-3-methoxy-phenylamino]-3-methyl-butyric acid benzyl ester 

Relevant academic research and scientific papers

Synthesis of 7,8-disubstituted benzolactam-V8 and its binding to protein kinase C

7-methoxy-8-decynyl-benzolactam-V8 4 is synthesized using a catalytic asymmetric alkylation reaction as a key step. This compound shows potent activity to three PKC isozymes tested (Ki = 45.6, 91.1, and 121.3 nM to PKCα, δ, and ε, respectively), indicating that introduction of a suitable substituent at the 7-position of 8-decynyl-benzolactam-V8 only slightly reduces the PKC binding affinity.

Synthesis of 7-methoxybenzolactam-V8 using a diastereoselective Strecker synthesis

7-Methoxybenzolactam-V8 (4) was synthesized using a diastereoselective Strecker reaction as the key step employing an ortho-substituted phenylacetaldehyde and (R)-phenylglycinol as the chiral auxiliary.