358366-16-2Relevant academic research and scientific papers
A stereochemically flexible approach to pyrrolidines based on 5-endo-trig iodocyclisations of homoallylic sulfonamides
Jones,Knight,Hibbs
, p. 1182 - 1203 (2007/10/03)
5-endo-trig Iodocyclisations of the (E)-homoallylic sulfonamides 24 in the presence of potassium carbonate give excellent yields of trans-2,5-disubstituted-3-iodopyrrolidines 36. In the absence of base, these initial kinetic products undergo rapid isomeri
A new, highly stereoselective approach to pyrrolidines via overall 5-endo-trig cyclisations of homoallylic tosylamides
Jones, Andrew D.,Knight, David W.
, p. 915 - 916 (2007/10/03)
Iodocyclisations of E-homoallylic tosylamides 7 lead to excellent yields of either 2,5-trans- or 2,5-cis-3-iodopyrrolidines (10 or 11), depending upon the reaction conditions.
