358722-20-0

Basic information

• Product Name: tert-butyl 4-(3-chlorophenyl)-5,6-dihydropyridine-1(2H)-carboxylate
• Synonyms: tert-butyl 4-(3-chlorophenyl)-5,6-dihydropyridine-1(2H)-carboxylate
• CAS NO: 358722-20-0
• Molecular Weight: 293.793
• Mol File: 358722-20-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-(3-chlorophenyl)-5,6-dihydropyridine-1(2H)-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(3-chlorophenyl)-5,6-dihydropyridine-1(2H)-carboxylate(358722-20-0)
• EPA Substance Registry System: tert-butyl 4-(3-chlorophenyl)-5,6-dihydropyridine-1(2H)-carboxylate(358722-20-0)

Safety Data

• Hazardous Substances Data: 358722-20-0(Hazardous Substances Data)

Upstream product

• 63503-60-6 3-chlorophenylboronic acid 
• 138647-49-1 4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 871112-37-7 tert-butyl 4-(3-chlorophenyl)-4-hydroxypiperidine-1-carboxylate 
• 375853-82-0 tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate 

Downstream Products

• 95884-51-8 4-(3-chlorophenyl)-1,2,3,6-tetrahydropyridine 
• 1241898-78-1 tert-butyl (5-{2-[4-(3-chlorophenyl)-3,6-dihydropyridin-1(2H)-yl]-1,3-thiazol-5-yl}-2H-tetrazol-2-yl)acetate 
• 1241896-55-8 (5-{2-[4-(3-chlorophenyl)-3,6-dihydropyridin-1(2H)-yl]-1,3-thiazol-5-yl}-2H-tetrazol-2-yl)acetic acid 
• 99329-53-0 4-(3-chlorophanyl)piperidine 

Relevant articles and documents

Compound as potassium channel modulator

The invention relates to a compound as a potassium channel modulator, which is a compound of a formula (I) or a pharmaceutically acceptable salt thereof. The compound or the pharmaceutically acceptable salt thereof is effective for curing and preventing diseases and symptoms influenced by the activity of potassium ion channels.

HETEROCYCLIC DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE

Heterocyclic compounds of structural formula (I), or a pharmaceutically acceptable salt thereof, wherein W is a R1— substituted heteroaryl, R1 is an heteroaryl ring substituted with an ester or carboxylic acid containing radical, X-T is N—CR5R6, C═CR5 or CR13—CR5R6, Y is a bond or —C(O)—, a and b represent an integer selected from 1 to 4, and Ar is an optionally substituted phenyl or naphtyl, are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD) The heterocyclic compounds are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, atherosclerosis, obesity, diabetes, neurological disease, Metabolic Syndrome, insulin resistance, cancer, liver steatosis, and non-alcoholic steatohepatitis.

Design, synthesis, and evaluation of novel aryl-tetrahydropyridine PPARα/γ dual agonists

Aryl-tetrahydropyridine derivatives were prepared and their PPARα/γ dual agonistic activities were evaluated. Among them, compound (S)-5b was identified as a potent PPARα/γ dual agonist with an EC50 of 1.73 and 0.64 μM in hPPARα and γ, respectively. In diabetic (db/db) mice, compound (S)-5b showed good glucose lowering efficacy and favorable pharmacokinetic properties.