99329-53-0 Usage
Uses
Used in Pharmaceutical Research and Development:
4-(3-CHLOROPHENYL)PIPERIDINE is used as a key intermediate in the synthesis of various pharmaceutical compounds for its potential to modulate central nervous system functions. It is particularly valuable in the development of drugs targeting neurological and psychiatric disorders due to its ability to interact with specific brain receptors and pathways.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 4-(3-CHLOROPHENYL)PIPERIDINE is used as a building block for designing and creating novel molecules with therapeutic potential. Its structural features allow for the fine-tuning of drug candidates to enhance their efficacy, selectivity, and safety profiles.
Used in Chemical Synthesis:
4-(3-CHLOROPHENYL)PIPERIDINE is employed as a versatile reagent in chemical synthesis, enabling the creation of a wide range of chemical products. Its unique structure facilitates various chemical reactions, contributing to the synthesis of complex organic molecules.
Used in Organic Chemistry:
In organic chemistry, 4-(3-CHLOROPHENYL)PIPERIDINE serves as a model compound for studying reaction mechanisms and exploring new synthetic methodologies. Its presence in various chemical reactions provides insights into the behavior of similar piperidine derivatives and their potential applications in the development of new chemical entities.
Check Digit Verification of cas no
The CAS Registry Mumber 99329-53-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,9,3,2 and 9 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 99329-53:
(7*9)+(6*9)+(5*3)+(4*2)+(3*9)+(2*5)+(1*3)=180
180 % 10 = 0
So 99329-53-0 is a valid CAS Registry Number.
InChI:InChI=1/C11H14ClN/c12-11-3-1-2-10(8-11)9-4-6-13-7-5-9/h1-3,8-9,13H,4-7H2
99329-53-0Relevant academic research and scientific papers
Design, synthesis and evaluation of substituted piperidine based KCNQ openers as novel antiepileptic agents
Yang, Shaoning,Lu, Dingqiang,Ouyang, Pingkai
supporting information, p. 1731 - 1735 (2018/05/04)
Epilepsy is a kind of disease with complicated pathogenesis. KCNQ (Kv7) is a voltage dependent potassium channel that is mostly associated with epilepsy and thus becomes an important target in the treatment of epilepsy. In this paper, a series of substituted piperidine derivatives targeting KCNQ were designed and synthesized by using scaffold hopping and active substructure hybridization. Compounds were evaluated by fluorescence-based thallium influx assay, Rb+ flow assay and electrophysiological patch-clamp assay. Results showed that some compounds possessed more potent potassium channel opening activity than Retigabine. More significantly, compound 11 was found to have good pharmacokinetic profiles in vivo.
Superacid-catalyzed preparation of aryl-substituted piperidines via dicationic electrophiles
Klumpp, Douglas A.,Beauchamp, Philip S.,Sanchez Jr., Gregorio V.,Aguirre, Sharon,De Leon, Sarah
, p. 5821 - 5823 (2007/10/03)
The electrophilic chemistry of 1,2,3,6-tetrahydropyridines has been studied in the Bronsted superacid, CF3SO3H (triflic acid). The 1,2,3,6-tetrahydropyridines react with arenes to give aryl-substituted piperidines. It is proposed tha
SYNTHESE ET ACTIVITE ANTI-DEPRESSIVE POTENTIELLE DE NOUVELLES TRIAZINE-1,2,3-ONES-4
Ferrand, Gerard,Dumas, Herve,Depin, Jean-Claude,Chavernac, Gilles
, p. 337 - 346 (2007/10/02)
Synthesis of new 1,2,3-triazin-4-ones as potential anti-depressants.A series of 1,2,3-triazin-4-ones was prepared and examined for potential anti-depressive activity by comparison with trazodone 2.Several of them show a potentiation of the central effects
