358968-59-9

Upstream product

• 118-90-1 ortho-methylbenzoic acid 
• 947395-59-7 1-(azidomethyl)-2-(phenylethynyl)benzene 
• 933-88-0 ortho-toluoyl chloride 
• 2170-09-4 N,2-dimethylbenzamide 

Relevant academic research and scientific papers

Reaction of 3-substituted and 4-bromo-3-substituted isoquinolin-1-(2H)-ones with propargyl bromide

Isoquinolinones were brominated using N-bromosuccinimide in dimethylformamide at room temperature to give 4-bromo-3-substituted isoquinolin-1-(2H)-ones. The reaction of these isoquinolinones with propargyl bromide in the presence of anhydrous potassium carbonate yielded N and O-alkylated products.

A selective synthesis of 4-bromoisoquinoline and 4-bromoisquinolone

2-Alkynyl benzyl azides smoothly underwent an electrocyclic reaction catalysed by palladium to selectively afford either 4-bromoisoquinoline and 4-bromoisquinolones under different conditions. 4-Bromoisoquinoline was synthesised in the presence of PdBrsu