358969-71-8

Basic information

• Product Name: 4-AMINO-1-N-ALLOC-PIPERIDINE
• Synonyms: 4-AMINO-1-N-ALLOC-PIPERIDINE;4-AMINO-1-N-ALOC-PIPERIDINE;4-AMINO-PIPERIDINE-1-CARBOXYLIC ACID ALLYL ESTER;1-Piperidinecarboxylicacid,4-amino-,2-propenylester(9CI);allyl 4-aminopiperidine-1-carboxylate;REF DUPL: 4-Amino-1-N-alloc-piperidine;Allyl 4-AMinopiperdine-1-carboxylate;1-Piperidinecarboxylic acid, 4-amino-, 2-propen-1-yl ester
• CAS NO: 358969-71-8
• Molecular Formula: C9H16N2O2
• Molecular Weight: 184.24
• Product Categories: CARBOXYLICESTER
• Mol File: 358969-71-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 271.1 °C at 760 mmHg
• Flash Point: 117.8 °C
• Appearance: /
• Density: 1.078 g/cm³
• Vapor Pressure: 0.00656mmHg at 25°C
• Refractive Index: 1.498
• CAS DataBase Reference: 4-AMINO-1-N-ALLOC-PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-1-N-ALLOC-PIPERIDINE(358969-71-8)
• EPA Substance Registry System: 4-AMINO-1-N-ALLOC-PIPERIDINE(358969-71-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• Hazardous Substances Data: 358969-71-8(Hazardous Substances Data)

Usage

Uses

Allyl 4-Aminopiperdine-1-carboxylate has been used as a reactant for the preparation of 4-aminopiperdine analogs.

InChI:InChI=1/C9H16N2O2/c1-2-7-13-9(12)11-5-3-8(10)4-6-11/h2,8H,1,3-7,10H2

Upstream product

• 40064-34-4 piperidine-4,4-diol hydrochloride 
• 306296-67-3 1-allyloxycarbonylpiperidin-4-one 

Relevant articles and documents

Solid-phase synthesis of 4-aminopiperidine analogues using the Alloc protecting group: An investigation of Alloc removal from secondary amines

A useful method for Alloc removal from secondary amines on solid-phase has been optimised. The use of Me2NH·BH3 (40 equiv., 40 min) as scavenger of the allyl cations in a palladium-catalysed process with Pd[PPh3]4 leads to quantitative removal of the Alloc group without any allyl back alkylation. Other scavengers such as morpholine or PhSiH3 are clearly inferior. Furthermore, this study has highlighted differences in the reaction kinetics of the deprotection step between secondary and primary amines such as those from α-amino acids.