358980-65-1Relevant academic research and scientific papers
Synthesis and crystal structure of 1-benzhydryl-4-methane-sulfonyl- piperazine
Naveen,Sridhar,Prasad, J. Shashidhara,Kumar, C. S. Ananda,Prasad, S. B. Benaka,Thimmegowda,Rangappa
, p. 67 - 76 (2007)
The title compound, 1-benzhydryl-4-methanesulfonyl-piperazine, was synthesized by the nucleophilic substitution of 1-benzhydryl-piperazine with methyl sulfonyl chloride. The product obtained was characterized by spectroscopic techniques, and the structure was investigated by X-ray crystallography. The compound crystallizes in the monoclinic crystal class in the space group P21/c with cell parameters a=9.5820(4) A, b=16.8150(12) A, c=13.5280(8) A, =127.270(5), and V=1734.5(2)A3 for Z=4. The structure reveals that the piperazine ring is in a chair conformation. There is a large discrepancy around the bond angles of the piperazine N atoms. The geometry around the S atom is distorted tetrahedral.
Synthesis and evaluation of 1-benzhydryl-sulfonyl-piperazine derivatives as inhibitors of MDA-MB-231 human breast cancer cell proliferation
Ananda Kumar,Nanjunda Swamy,Thimmegowda,Benaka Prasad,Yip, George W.,Rangappa
, p. 179 - 187 (2008/09/17)
A series of novel 1-benzhydryl-sulfonyl-piperazine derivatives 7(a-e) were designed by a nucleophilic substitution reaction of 1-benzhydryl-piperazine with various sulfonyl chlorides and characterized by 1H nuclear magnetic resonance (NMR), liquid chromatography mass spectrometry (LC/MS), Fourier-transform infrared (FTIR), and elemental analysis. Our research is focused on identifying synthetically occurring chemotherapeutic substances capable of inhibiting, retarding, or reversing the process of multistage carcinogenesis. The title compounds were evaluated for their efficacy in inhibiting MDA-MB-231 breast cancer cell proliferation. Compound 1-benzhydryl-4-(4-tert-butyl-benzenesulfonyl)-piperazine (7d) showed significant inhibitory activity. Birkhaeuser 2007.
