3590-12-3Relevant articles and documents
Selective Detection of Cu+ Ions in Live Cells via Fluorescence Lifetime Imaging Microscopy
Kuimova, Marina K.,Lewis, Benjamin W.,Priessner, Martin,Sastre, Magdalena,Summers, Peter A.,Vilar, Ramon,Ying, Liming
supporting information, p. 23148 - 23153 (2021/09/20)
Copper is an essential trace element in living organisms with its levels and localisation being carefully managed by the cellular machinery. However, if misregulated, deficiency or excess of copper ions can lead to several diseases. Therefore, it is impor
Tracking Labile Copper Fluctuation in Vivo/ Ex Vivo: Design and Application of a Ratiometric Near-Infrared Fluorophore Derived from 4-Aminostyrene-Conjugated Boron Dipyrromethene
Xu, Hongxia,Yao, Shankun,Chen, Yuncong,Zhang, Changli,Zhang, Shuren,Yuan, Hao,Chen, Zhongyan,Bai, Yang,Yang, Tao,Guo, Zijian,He, Weijiang
, p. 18567 - 18574 (2021/12/09)
Specimen differences, tissue-dependent background fluorescence and scattering, and deviated specimen position and sensor concentration make optical imaging for labile copper fluctuation in animals questionable, and a signal comparison between specimens is
Redox triggered aggregation induced emission (AIE) polymers with azobenzene pendants
Wu, Bing,Wang, Wei,Wang, Jilei,Li, Shang,He, Yaning
, p. 290 - 297 (2018/05/24)
We reported the redox triggered aggregation induced emission (AIE) polymers with azobenzene pendants. Tetraphenylethene (TPE) based polymers with selected degrees of functionalization of azobenzene chromophores were synthesized through a post-polymerizati
Synthesis, characterization and theoretical investigations of molybdenum carbonyl complexes with phosphorus/nitrogen/phosphorus ligand as bidentate and tridentate modes
Goren Keskin, Seyma,Stanley, Julie M.,Cowley, Alan H.
, p. 206 - 217 (2017/10/16)
Carbonyl complexes of molybdenum with the phosphorus/nitrogen/phosphorus ligand, PNP-Mo(CO)n, where n = 3, 4 and PNP is N,N-bis[2-(diphenylphosphino)ethyl]phenylamine have been synthesized and characterized by 1H, 31P{1H} NMR, IR (ATR and solution state), Raman, X-ray diffraction, MS and elemental analysis. DFT calculations of the complexes were also performed. The PNP-Mo(CO)4 complex in which the binding mode is bidentate cis-phosphine and, facial and meridional isomers of PNP-Mo(CO)3 in which the binding mode is tridentate were obtained. The facial isomer and the tetracarbonyl complexes were successfully synthesized and purified; however, it was not possible to isolate the meridional isomer. Only a few crystals of the meridional isomer were detected and used for X-ray analysis. When the facial isomer was dissolved in CH2Cl2 or in THF, it was found to undergo decomposition thereby generating the tetracarbonyl complex, meridional isomer, Mo(0) as a dark precipitate along with some facial isomer that was left intact in solution. The reason that the facial isomer was the preferred structure with respect to the meridional isomer was also investigated.
Molybdenum dinitrogen complexes facially coordinated by linear tridentate PEP ligands (E = N or P): Impact of the central e donor in: Trans -position to N2
Hinrichsen, Svea,Schnoor, Ann-Christin,Grund, Katharina,Fl?ser, Benedikt,Schlimm, Alexander,N?ther, Christian,Krahmer, Jan,Tuczek, Felix
supporting information, p. 14801 - 14813 (2016/09/28)
The syntheses of molybdenum dinitrogen complexes supported by the tridentate PEP ligands (E = N, P) prPP(Ph)P = (Ph2PCH2CH2CH2)2P(Ph), prPPHP = (Ph2PCH2CH2CH2)2PH, PN(Ph)P = (Ph2PCH2CH2)2N(Ph) and prPN(Ph)P = (Ph2PCH2CH2CH2)2N(Ph) are reported. Together with the coligand dmpm = (CH3)2PCH2P(CH3)2 dinitrogen complexes of the type [Mo(N2)(PEP)(dmpm)] are formed. The new systems are characterized by IR and NMR spectroscopy and compared with the literature-known complex [Mo(N2)(dpepp)(dmpm)] (1) (dpepp = PhP(CH2CH2PPh2)2). The consequences of the substitution of the central P-donor of dpepp by N and the replacement of its C2 by C3 linkages as well as the exchange of the EPh by an EH function are investigated with respect to the stability of the corresponding N2-complexes. Importantly, the activation of the N2 ligand drastically increases upon replacing the trans-phosphine with a trans-amine donor.
α-Glucosidase inhibition and antihyperglycemic activity of flavonoids from Ampelopsis grossedentata and the flavonoid derivatives
Chen, Jia,Wu, Yuechan,Zou, Jianwei,Gao, Kun
, p. 1488 - 1494 (2016/03/16)
The dried leaves and stems of Ampelopsis grossedentata have been used as a health tea and herbal medicine for hundreds of years in China. The study was aimed at searching for novel α-glucosidase inhibitors among the richest components of A. grossedentata and their derivatives. Three known major components (1-3) were isolated by recrystallization process and six new derivatives (4-9) were obtained by etherification of the bioactive flavonoid. All compounds were evaluated for their inhibitory activities against α-glucosidase (from Saccharomyces cerevisiae). As a result, compound 9 showed a significant α-glucosidase inhibitory activity with IC50 value of 9.3 μM and acted as a competitive inhibitor with the value of the inhibition constant (Ki) being 10.3 μM. The oral administration of compound 9 at a dose of 50 mg/kg significantly reduced the post prandial blood glucose levels of normal and streptozotocin (STZ)-induced diabetic mice. Furthermore, compound 9 significantly decreased the fasting blood glucose levels in STZ-induced diabetic mice.
Synthesis of New Bis-1,2,4-Oxadiazoline Derivatives via 1,3-Dipolar Cycloaddition Reaction
Chen, Fei,Zeng, Hua,Liu, Fang-Ming
, p. 1866 - 1870 (2016/11/23)
A series of novel bis-oxadiazoline derivatives 4 was synthesized via 1,3-dipolar cycloaddition reaction of bis-aldimines 3, and nitrile oxides generated in situ from various benzohydroximinoyl chlorides in the presence of Et3N. The target products were confirmed by IR,1H-NMR, and mass spectrometry.
Synthesis and spectroscopic properties of new bis-tetrazoles
Pazik, Agnieszka,Skwierawska, Anna
, p. 83 - 94 (2014/01/06)
Syntheses of N,N′-phenyltetrazole podands link with aliphatic chains containing oxygen, nitrogen and sulphur atoms, are described. The complexing properties of these compounds towards metal cations (Fe2+, Cu 2+, Zn2+, Co2+, Ni2+) were investigated by absorption and infrared spectroscopy. The UV-Vis titrations were performed to estimate the stability constant values of the respective complexes with Cu2+ ion. Changes in UV-Vis absorption spectra and IR spectra of compound 6 under various concentrations of Cu2+ ion in methanol suggest formation of very unstable complex. The structure of ligand 2 has been deduced by X-ray crystallography. The Author(s) 2012.
A Carbazole-attached NO2S2-macrocycle exhibiting Hg2+ and Cu2+ selectivity
Lee, Seul-Gi,Kang, Eun-Ju,Lee, Shim Sung
, p. 1429 - 1434 (2013/07/28)
A synthesis and cation-induced fluorescent behavior of the carbazole-attached NO2S2-macrocycle (L) is described and structurally characterized by single crystal X-ray analysis. The photoluminescence spectrum of L in 80% CH3/sub
Steady-state and time-resolved investigations of a crown thioether conjugated with methylacridinium and its complexes with metal ions
Giacco, Tiziana Del,Carlotti, Benedetta,Solis, Stefano De,Barbafina, Arianna,Elisei, Fausto
experimental part, p. 2188 - 2195 (2011/09/30)
The crown thioether 9-[4-(4,7,10,13-tetrathia-1-azacyclopentadecyl]phenyl- N-methylacridinium perchlorate (TCMA) was synthesized and characterized with the aim to verify its ability to interact selectively with metal ions and substantiate the possibility to detect easily the presence of heavy metals in fluid samples. The spectroscopic properties of TCMA, alone and in the presence of metal ions, were therefore studied in polar solvents (MeCN and H 2O); in particular, steady-state UV-Vis spectrophotometric and fluorimetric techniques were used together with transient absorption spectroscopy with fs time resolution to investigate the spectral and dynamic properties of the lowest excited singlet state of TCMA and of TCMA/metal ion complexes. The absorption in the Vis region is characterized by a charge-transfer nature with the methylacridinium moiety acting as the electron-acceptor and the anilic group as the electron-donor. No emission from the S1 was detected both in MeCN and H2O, while a small S2 → S0 fluorescence emission (λmax = 485 nm and F = 0.0011) was detected in water. Time-resolved measurements with fs resolution of TCMA in MeCN have shown that the relaxed S1 state is reached ~0.6 ps after the laser pulse, while the S1 → S0 time constant is 3.7 ps. Among the investigated metal ions, only Fe3+ (in MeCN) and Hg2+ (in MeCN and H2O) were able to form stable complexes (association constant, Kass = 1-11 × 104 M-1) with TCMA. The S1 state of the TCMA/Mn+ complexes emits with low quantum yield (F = 0.0023-0.014) and decays with time constants much longer than TCMA itself, at least in the case of TCMA/Hg2+ in MeCN. This study showed that TCMA is a good candidate for colorimetric/ fluorimetric sensing of Hg2+ in aqueous media owing to its high selectivity towards metal ions. the Owner Societies.