359011-23-7

Upstream product

• 96-76-4 2,4-di-tert-Butylphenol 
• 20834-61-1 2-bromo-4,6-di-tert-butylphenol 
• 1066-54-2 trimethylsilylacetylene 
• 89209-02-9 4,6-di-tert-butyl-2-iodophenol 

Downstream Products

• 936856-64-3 4,6-di-tert-butyl-2-trimethylsilylethynyl-(3-butenyloxy)benzene 
• 936856-48-3 4,6-di-tert-butyl-2-trimethylsilylethynyl-(2-propenyloxy)benzene 
• 359011-24-8 2,4-di-tert-butyl-6-ethynyl-(2-propenyloxy)benzene 
• 936856-51-8 4,6-di-tert-butyl-2-trimethylsilylethynyl-(2-methylallyloxy)benzene 
• 936856-49-4 4,6-di-tert-butyl-2-trimethylsilylethynyl-(3-phenyl-2-propenyloxy)benzene 
• 359011-25-9 2,4-di-tert-butyl-6-ethynyl-(3-butenyloxy)benzene 
• 359011-26-0 2,4-di-tert-butyl-6-ethynyl-(4-pentenyloxy)benzene 
• 936856-52-9 4,6-di-tert-butyl-2-ethynyl-(2-methylallyloxy)benzene 
• 936856-50-7 4,6-di-tert-butyl-2-ethynyl-(3-phenyl-2-propenyloxy)benzene 

Relevant academic research and scientific papers

Biomimetic carbene cascades enabled imine derivative migration from carbene -bearing thiocarbamates

Inspired by the body circulation of Omeprazole (irreversible proton pump inhibitor), we disclose the carbene-triggered cascades for the synthesis of 2-aminobenzofuran derivatives from N-sulfonyl-1,2,3-triazoles or benzothioazole-bearing thiocarbamates, which represents an unprecedented imine derivative migration process. Furthermore, the desulfurizing reagent-free Barton-Kellogg-type reactions starting from N-sulfonyl-1,2,3-triazoles have also been achieved for the first time, and elemental sulfur is confirmed as a byproduct during this transformation. Both experimental data and DFT calculations further thoroughly explained the unique reactivity.

A new bis-phenolate mesoionic carbene ligand for early transition metal chemistry

We report the synthesis of a new pincer-type triazolylidene ligand precursor H3L[Cl] with redox-active 3,5-di-tert-butylphenolate substituents on a multigram scale following a converging ten-step route. The potential of this new mesoionic carbe

Steric buttressing in the Pauson-Khand reactions of aryl enynes

A variety of aryl enynes have been constructed from o-iodophenol derivatives containing ortho-tert-butyl groups via O-alkylation and a Sonogashira cross-coupling reaction. These substrates undergo efficient thermal and oxidative intramolecular Pauson-Khand reactions leading to the formation of sterically congested cyclopentenones, as well as the formation of medium-sized rings, although in the latter case with unusual regioselectivity. Incorporation of a TMS moiety on the alkyne group in a higher homolog led to cyclization via the normal mode, albeit in relatively low yield.

Synthesis of bridged medium-sized rings through the intramolecular Pauson-Khand reaction

(Equation presented) A series of aromatic enynes containing steric buttressing elements were prepared and evaluated in the NMO-mediated Pauson-Khand cyclization. O-Allyl systems led to the expected angularly fused products, whereas the O-butenyl and O-pentenyl derivatives afforded the unprecedented bridge systems.