35903-52-7

Basic information

• Product Name: FUMAGILLOL
• Synonyms: FUMAGILLOL;(3S,4R,5R,6S)-rel-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]octan-6-ol
• CAS NO: 35903-52-7
• Molecular Formula: C₁₆H₂₆O₄
• Molecular Weight: 282.38
• Mol File: 35903-52-7.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: Chlorofrom (Slightly), Ethanol (Slightly), Ethyl Acetate (Slightly), Methanol (S
• CAS DataBase Reference: FUMAGILLOL(CAS DataBase Reference)
• NIST Chemistry Reference: FUMAGILLOL(35903-52-7)
• EPA Substance Registry System: FUMAGILLOL(35903-52-7)

Safety Data

• Hazardous Substances Data: 35903-52-7(Hazardous Substances Data)

Upstream product

• 16666-80-1 triphenylphosphonio-1-methylethanide 
• 132746-88-4 Fumaginone 
• 41567-78-6 dicyclohexylamine (2E,4E,6E,8E)-10-(((3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl)oxy)-10-oxodeca-2,4,6,8-tetraenoate 
• 192931-83-2 (1R,2S,3S,4R)-1,4-Bis-benzyloxy-3-methoxy-2-((E)-1-methyl-penta-1,4-dienyl)-cyclohexanecarboxylic acid methyl ester 
• 192932-02-8 [(1R,2S,3S,4R)-1,4-Bis-benzyloxy-3-methoxy-2-((E)-1-methyl-penta-1,4-dienyl)-cyclohexyl]-methanol 
• 192931-93-4 Toluene-4-sulfonic acid (1R,2S,3S,4R)-1,4-dihydroxy-3-methoxy-2-((E)-1-methyl-penta-1,4-dienyl)-cyclohexylmethyl ester 
• 192931-95-6 (3R,4S,5S,6R)-4-((2R,3R)-3-Allyl-2-methyl-oxiranyl)-5-methoxy-1-oxa-spiro[2.5]octan-6-ol 
• 192931-92-3 (1R,2S,3S,4R)-1-Hydroxymethyl-3-methoxy-2-((E)-1-methyl-penta-1,4-dienyl)-cyclohexane-1,4-diol 
• 192931-94-5 (3R,4S,5S,6R)-4-((E)-hexa-2,5-dien-2-yl)-5-methoxy-1-oxaspiro[2.5]octan-6-ol 
• 682746-13-0 (R)-7-(N-phenyl-aminooxy)-2,3-dioxa-spiro[4.5]decan-8-one 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 877052-55-6 Toluene-4-sulfonic acid (1R,2S,3S)-2-((E)-1,5-dimethyl-hexa-1,4-dienyl)-1,3-dihydroxy-4-oxo-cyclohexylmethyl ester 
• 877052-53-4 (1R,2R)-1-(tert-Butyl-dimethyl-silanyloxymethyl)-2-((E)-1,5-dimethyl-hexa-1,4-dienyl)-4-trimethylsilanyloxy-cyclohex-3-enol 
• 877052-50-1 (7R,8S)-7,8-Bis-trimethylsilanyloxy-1,4-dioxa-spiro[4.5]decane-8-carbonitrile 

Downstream Products

• 129298-89-1 6-O-(2-carboxybenzoyl)fumagillol 
• 129299-11-2 (3R,4S,5S,6R)-4-((2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl)-5-(oxo-λ⁶-methyl)-1-oxaspiro[2.5]octan-6-yl acetylcarbamate 
• 129298-91-5 6-O-chloroacetylcarbamoylfumagillol 
• 129298-96-0 6-O-(3-trifluoromethylphenylcarbamoyl)fumagillol 
• 129299-13-4 6-O-benzoylcarbamoylfumagillol 
• 251111-15-6 CDK-731 
• 94462-96-1 (1R)-2c-((1S,2Ξ)-1,2-epoxy-1,5-dimethyl-hexyl)-3t-methoxy-1-methyl-cyclohexane-1r,4t-diol 
• 129299-00-9 6-O-benzylfumagillol 
• 1160640-95-8 carbonic acid-(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-but-2-enyl)-oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester 4-nitro-phenyl ester 
• 1399361-15-9 C₃₃H₄₈O₇ 
• 1399360-52-1 (2S,4R)-4-hydroxy-3-((2R,3R)-3-isopentyl-2-methyloxiran-2-yl)-2-methoxy-4-methylcyclohexanone 
• 1399361-44-4 C₂₀H₂₅NO₅ 
• 1401999-53-8 7-bromo-6-(3-carboxy-1-oxopropyl)-fumagillol 
• 1401999-51-6 7-chloro-6-(4-carboxy-1-oxobutoxy)-fumagillol 

Relevant articles and documents

PRODRUG COMPOSITIONS, PRODRUG NANOPARTICLES, AND METHODS OF USE THEREOF

The present invention encompasses prodrug compositions, nanoparticles comprising one or more prodrugs, and methods of use thereof.

Remodeling of fumagillol: Discovery of an oxygen-directed oxidative mannich reaction

An efficient, two-step construction of highly complex alkaloid-like compounds from the natural product fumagillol is described. This approach, which mimics a biosynthetic cyclase/oxidase sequence, allows for rapid and efficient structure elaboration of th

Ligerin, an antiproliferative chlorinated sesquiterpenoid from a marine-derived penicillium strain

A new chlorinated sesquiterpenoid analogue of fumagillin, ligerin (1), was isolated from a marine-derived strain of Penicillium, belonging to the subgenus Penicillium, along with the known compounds penicillic acid (2), orcinol, and orsellinic acid. Chemical structures were established by an interpretation of spectroscopic data including IR, UV, and HRESIMS, together with analyses of 1D and 2D NMR spectra and X-ray analysis for the determination of the absolute configuration. Ligerin (1) displayed strong inhibitory activity against an osteosarcoma cell line. This is the first report of the isolation of a fumagillin analogue from a marine-derived Penicillium strain.