35911-17-2Relevant academic research and scientific papers
Synthesis and biological activity of 2-aminoimidazole triazoles accessed by Suzuki-Miyaura cross-coupling
Reyes, Samuel,Huigens Iii, Robert W.,Su, Zhaoming,Simon, Michel L.,Melander, Christian
experimental part, p. 3041 - 3049 (2011/06/09)
A pilot library of 2-aminoimidazole triazoles (2-AITs) was synthesized and assayed against Acinetobacter baumannii and methicillin-resistant Staphylococus aureus (MRSA). Results from these studies show that these new derivatives have improved biofilm dispersal activities as well as antibacterial properties against A. baumannii. With MRSA biofilms they are found to possess biofilm inhibition capabilities at low micromolar concentrations.
Stereoselective synthesis of 2-dienyl-substituted pyrrolidines using an η4-dienetricarbonyliron complex as the stereodirecting element: Elaboration to the pyrrolizidine skeleton
Williams, Iwan,Kariuki, Benson M.,Reeves, Keith,Cox, Liam R.
, p. 4389 - 4392 (2007/10/03)
Primary amines react with keto-aldehyde functionality located in the side-chain of an η4-dienetricarbonyliron complex to provide the corresponding pyrrolidines in excellent diastereoselectivity. Two of the pyrrolidine products, 1i and 1k, have been elaborated into pyrrolizidines using a 1,5-C-H insertion and radical cyclization strategy, respectively.
Palladium-Catalyzed Syntheses of Conjugated Polyenes
Fischetti, William,Mak, K. Tim,Stakem, F. Gregory,Kim, Jin-Il,Rheingold, Arnold L.,Heck, Richard F.
, p. 948 - 955 (2007/10/02)
Conjugated trienes have been prepared by the palladium-catalyzed reaction of vinylic bromides with 2,4-pentadienoic acid and its 3-methyl derivative, in the presence of triethylamine.Methyl (E)-3-bromo-2-methylpropenoate also forms conjugated trienes and in some instances also tetraenes when it is reacted with 1,3-dienes under similar conditions.Some loss of stereochemistry in the starting vinylic bromide or, more often, in the diene may occur in the rections presumably because equilibrating ?-allylic intermediates are involved.1,3,5-Hexatriene and 2 equiv of methyl (E)-3-bromo-3-methylpropenoate form orange-red dimethyl (E,E,E,E,E)-2,11-dimethyl-2,4,6,8,10-dodecapentaenedioate in modest yield.
