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84695-29-4

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84695-29-4 Usage

Description

(E)-3-Bromo-2-methyl-2-propen-1-ol is an organic compound with the chemical formula C4H7BrO. It is a chiral molecule with a double bond and a bromine atom, which gives it unique chemical properties and reactivity. (E)-3-BroMo-2-Methyl-2-propen-1-ol is known for its role in the synthesis of various biologically active compounds and pharmaceuticals.

Uses

Used in Pharmaceutical Industry:
(E)-3-Bromo-2-methyl-2-propen-1-ol is used as a key intermediate in the stereoselective and enantioselective preparation of omuralide, 7-epi-omuralide, and lactacystin. These compounds have significant biological activities and potential applications in the development of new drugs for the treatment of various diseases.
In the synthesis of omuralide, (E)-3-Bromo-2-methyl-2-propen-1-ol serves as a starting material, which undergoes a series of chemical reactions to form the final product. Omuralide is a potent immunosuppressive agent that has been used in the treatment of autoimmune diseases and transplantation.
7-epi-Omuralide, a derivative of omuralide, is also synthesized using (E)-3-Bromo-2-methyl-2-propen-1-ol as a key intermediate. It exhibits similar biological activities as omuralide and has potential applications in the pharmaceutical industry.
Lactacystin, another compound synthesized using (E)-3-Bromo-2-methyl-2-propen-1-ol, is a potent and selective inhibitor of the 20S proteasome. It has been extensively studied for its potential use in the treatment of cancer and neurodegenerative diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 84695-29-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,6,9 and 5 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 84695-29:
(7*8)+(6*4)+(5*6)+(4*9)+(3*5)+(2*2)+(1*9)=174
174 % 10 = 4
So 84695-29-4 is a valid CAS Registry Number.

84695-29-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (E)-3-bromo-2-methyl-prop-2-en-1-ol

1.2 Other means of identification

Product number -
Other names (E)-3-Bromo-2-methyl-2-propen-1-ol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:84695-29-4 SDS

84695-29-4Relevant articles and documents

Single-electron/pericyclic cascade for the synthesis of dienes

Campbell, Natalie E.,Sammis, Glenn M.

supporting information, p. 6228 - 6231 (2014/06/23)

The highly efficient and diastereoselective synthesis of E dienes has been accomplished through radical cyclization of bromoallyl hydrazones. This methodology has been further extended to generate these products through a one-pot condensation/radical cyclization/cycloreversion cascade from simple aldehyde starting materials in high yields (>75 %) and high diastereoselectivities (>95:5). Mechanistic investigations suggest that the cascade reaction proceeds through a cyclic diazene intermediate prior to the cycloreversion.

Synthesis of the Conjugated Tetraene Acid Side Chain of Mycolactone e by Suzuki-Miyaura Cross-Coupling Reaction of Alkenyl Boronates

Wang, Yuan,Dai, Wei-Min

supporting information, p. 323 - 330 (2015/10/05)

The conjugated tetraene acid side chain of mycolactone E has been synthesized by the cross-coupling reaction of a trisubstituted triene bromide with a trisubstituted alkenyl boronate catalyzed by Pd(OAc)2-Aphos-Y under mildly basic conditions [K3PO4·3H2O, H2O, tetrahydrofuran (THF), 35 C, 18 h]. The conjugated tetraene product was obtained in 85 % yield without geometrical isomer(s) under the catalytic conditions. These results demonstrated that the coupling of alkenyl halides with alkenyl boronates catalyzed by Pd(OAc)2-Aphos-Y in combination with CuI-catalyzed regio- and stereoselective alkyne borylation offers an efficient synthetic tool for accessing conjugated polyene molecules.

Studies on the synthesis of apoptolidin A. 1. Synthesis of the C(1)-C(11) fragment

Handa, Masaki,Scheldt, Karl A.,Bossart, Martin,Zheng, Nan,Roush, William R.

, p. 1031 - 1035 (2008/09/18)

(Chemical Equation Presented) A synthesis of the C(1)-C(11) fragment of apoptolidin A has been accomplished by a convergent route involving the stereoselective glycosidation of 9 and the Suzuki cross-coupling reaction of bromodienoate 7 and the vinylboran

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