35921-35-8

Basic information

• Product Name: 1-benzyl-4-benzylidenepyrrolidine-2,3-dione
• CAS NO: 35921-35-8
• Molecular Formula: C₁₈H₁₅NO₂
• Molecular Weight: 277.3172
• Mol File: 35921-35-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 454.6°C at 760 mmHg
• Flash Point: 206.1°C
• Density: 1.267g/cm³
• Vapor Pressure: 1.88E-08mmHg at 25°C
• Refractive Index: 1.673
• CAS DataBase Reference: 1-benzyl-4-benzylidenepyrrolidine-2,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-4-benzylidenepyrrolidine-2,3-dione(35921-35-8)
• EPA Substance Registry System: 1-benzyl-4-benzylidenepyrrolidine-2,3-dione(35921-35-8)

Safety Data

• Hazardous Substances Data: 35921-35-8(Hazardous Substances Data)

Usage

General Description

1-benzyl-4-benzylidenepyrrolidine-2,3-dione, also known as ω-conotoxin MVIIA, is a potent neurotoxin found in the venom of the marine snail Conus magus. 1-benzyl-4-benzylidenepyrrolidine-2,3-dione selectively blocks N-type calcium channels, which are important for the transmission of pain signals in the nervous system. As a result, ω-conotoxin MVIIA has been studied for its potential use as a painkiller, particularly in the treatment of severe and chronic pain conditions. By inhibiting the influx of calcium ions into nerve cells, this toxin can effectively reduce the release of neurotransmitters involved in pain signaling, providing relief for patients. Additionally, research has shown potential applications for ω-conotoxin MVIIA in the treatment of neurological disorders, such as epilepsy and Parkinson's disease, due to its ability to modulate calcium channel activity in the brain. However, further studies are needed to fully understand the pharmacological properties and potential therapeutic benefits of this compound.

Upstream product

• 5336-41-4 methyl 1-benzyl-4,5-dioxopyrrolidine-3-carboxylate 
• 100-52-7 benzaldehyde 
• 6436-90-4 ethyl 2-(benzylamino)acetate 
• 5336-50-5 1-benzyl-4,5-dioxopyrrolidine-3-carboxylic acid ethyl ester 

Downstream Products

• 95275-90-4 1,4-dibenzylpyrrolidine-2,3-dione 

Relevant articles and documents

η6-Arene CH?O Interaction Directed Dynamic Kinetic Resolution – Asymmetric Transfer Hydrogenation (DKR-ATH) of α-Keto/enol-Lactams

A dynamic kinetic resolution – asymmetric transfer hydrogenation (DKR-ATH) methodology of α-keto/enol-lactams was developed. We also propose a possible catalytic mechanism evolving a transition state stabilized by η6-arene CH?O interaction. The efficient approach can be applied to a wide range of substrates including non-aryl ones which would be difficult to prepare by other asymmetric reduction methods. (Figure presented.).

NHC-catalyzed asymmetric α-regioselective [4 + 2] annulation to construct α-alkylidene-δ-lactones

The unprecedented NHC-catalyzed [4 + 2] annulation of α-bromoenals with dioxopyrrolidines is described. This protocol features broad substrate scope and allows rapid assembly of α-alkylidene-δ-lactones in good to high yields with excellent enantioselectivities. Notably, this process includes α-regioselective activation of azolium dienolate intermediates, which has not yet been reported.

Oxoindolespiro tetrahydrofuran fluoride, crystal, preparation method and application thereof

The invention discloses oxoindolespiro tetrahydrofuran fluoride and a preparation method thereof. The structural formula of oxoindolespiro tetrahydrofuran fluoride is shown as formula I. The inventionfurther discloses a crystal form of a compound shown as the formula I, the crystal form is a monoclinic system, cell parameters include that a=9.09964(19) angstrom, b=9.3177(3) angstrom, c=15.6040(4)angstrom, alpha is equal to 90 degrees, beta is equal to 99.228 (2) degrees, and gamma is equal to 90 degrees; space group is P21, Z=2, and cell volume is 1305.91(6) angstrom. The invention further discloses a preparation method of the crystal form, the compound or the crystal form thereof or a solvate thereof or application of pharmaceutically acceptable salt thereof in preparing antitumor drug.