35929-86-3

Upstream product

• 870-64-4 2-aminocrotononitrile 
• 104919-31-5 3-oxo-2-[1-phenylmeth-(E)-ylidene]butyronitrile 
• 25907-38-4 ethyl 4-(phenylthio)-acetoacetate 
• 763-33-7 (E)-3-aminocrotononitrile 
• 100-52-7 benzaldehyde 
• 149590-40-9 3-aminocrotonitrile anion 
• 936-50-5 2-phenylthiazolidine hydrochloride 

Downstream Products

• 109329-72-8 3,5-Dicyano-1,2,6-trimethyl-4-phenyl-1,4-dihydropyridine 
• 109329-75-1 3β,5-Dicyano-1,2,3α-trimethyl-2-methylene-4β-phenyl-1,2,3,4-tetrahydropyridine 
• 1068639-41-7 C₁₇H₁₂F₃N₃O 
• 1068639-46-2 N-(2,4-dicyano-1,5-dimethyl-3-phenylcyclopenta-2,4-dienyl)-2',2',2'-trifluoroacetamide 
• 74203-39-7 (3r,5r,7r)-1-(phenylethynyl)adamantane 
• 4250-82-2 (3,3-dimethyl-but-1-ynyl)benzene 

Relevant academic research and scientific papers

Synthesis of 2,3,4,7-tetrahydro[1,4]thiazepines from thiazolidines and β-enaminonitriles

A wide library of 2,3,4,7-tetrahydro[1,4]thiazepines have been prepared by simple heating of thiazolidine and β-enaminonitrile derivatives in acetonitrile. The procedure, whose yields depend on the nature and position of the substituents, gave good results if the substituents were not very bulky but it is less effective when starting from 2-substituted thiazolidines.

Preparation of 2,6-dimethyl-4-arylpyridine-3,5-dicarbonitrile: A paired electrosynthesis

Electrolysis of benzylthiocyanate, benzyl chloride, p-methylbenzyl chloride, p-methoxybenzyl chloride, or toluene in acetonitrile, at platinum electrodes in a two compartments cell divided by a glass-frit diaphragm, affords 2,6-dimethyl-4-arylpyridine-3,5

Calcium channel blocking and positive inotropic activities of ethyl 5-cyano-1,4-dihydro-6-methyl-2-[(phenylsulfonyl)methyl]-4-aryl-3-pyrid ine-carboxylate and analogues. Synthesis and structure-activity relationships

The synthesis and pharmacological evaluation of a series of 2-[(arylsulfonyl)methyl]-4-aryl-5-cyano-1,4-dihydropyridine-3-carboxyl ic acid esters and analogues are described. These compounds possess a unique profile namely, calcium channel blocking and positive inotropic activities in vitro. Compound 54 was selected as the best compound in the series and was studied in detail. The synthesis and biological profiles of enantiomers of 54 are also reported. The data indicate that although the calcium channel blocking property of 54 is stereospecific the positive inotropic activity is not. Examples of 3- and 6-cyano and other closely related 1,4-dihydropyridine derivatives are described and evaluated for comparison and were found to be devoid of dual activities mentioned above.

EQUILIBRIUM NH-ACIDITY OF 1,4-DIHYDROPYRIDINES AND 4,5-DIHYDROINDENOPYRIDINES

The patterns governing the dependence of NH-acidity on the presence of α-, β- and γ-substituents in the 1,4-dihydropyridine ring and on their nature have been established by comparison of the pKa values of monocyclic 1,4-dihydropyridines and 4,