3593-85-9

Basic information

• Product Name: Methandriol dipropionate
• Synonyms: 17ALPHA-METHYLANDROSTENDIOL DIPROPIONATE;METHANDRIOL DIPROPIONATE;17a-Methyl-5-androstene-3B,17B-diol Dipropionate;METHANDRIOL DIPROPIONATE ENTERPRISE STANDARD =98%;17α-Methyl-5-androstene-3β,17β-diol dipropionate;Androst-5-ene-3,17-diol, 17-methyl-, dipropanoate, (3.beta.,17.beta.)-;17-Methylandrost-5-ene-3b,17b-diol dipropionate;Methylandrostendiol dipropionate
• CAS NO: 3593-85-9
• Molecular Formula: C₂₆H₄₀O₄
• Molecular Weight: 416.6
• EINECS: 222-735-8
• Product Categories: Steroids
• Mol File: 3593-85-9.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 479.139 °C at 760 mmHg
• Flash Point: 227.952 °C
• Appearance: /
• Density: 1.09 g/cm³
• CAS DataBase Reference: Methandriol dipropionate(CAS DataBase Reference)
• NIST Chemistry Reference: Methandriol dipropionate(3593-85-9)
• EPA Substance Registry System: Methandriol dipropionate(3593-85-9)

Safety Data

• Hazard Codes: Xn
• Statements: 40
• Safety Statements: 36/37
• RIDADR: 3249
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 3593-85-9(Hazardous Substances Data)

Usage

Description

Methandriol dipropionate (MADP), also known as methylandrostenediol dipropionate and sold under the brand names Arbolic, Durabolic, Or-Bolic, Probolik, and Protabolin among others, is a synthetic, injected anabolic-androgenic steroid (AAS) and a 17α-alkylated derivative of 5-androstenediol. It is an androgen ester – specifically, the C3,17β dipropionate ester of methandriol (17α-methyl-5-androstenediol) – and acts as a prodrug of methandriol in the body. Methandriol dipropionate is administered by intramuscular injection and, relative to methandriol, has an extended duration via this route of several days due to a depot effect afforded by its ester. It was marketed in the United States,but is no longer available in this country.https://en.wikipedia.org/wiki/Methandriol_dipropionate

Uses

Methandriol Dipropionate is a longer-acting form of Methandriol dissolved in water. The drug has strong anabolic and androgenic components, and is designed to build strength and muscle mass. Its action can be compared to the action of a combination such as Deca-Durabolin + Testosterone Enanthate. Like testosterone, it contributes to a good increase in strength and mass, but it does not accumulate more water than Deca-Durabolin. Better results can be achieved by taking it not alone, but in combination with some other steroid.

Side effects

Methandriol dipropionate is a potent anabolic and androgenic properties is characterized by sufficient. As evidenced in Dipropionateratings, above the recommended dosing can be observed estrogenic side effects such as increase in the amount of adipose tissue and water retention.There are a few adverse reactions associated with the use of methandriol dipropionate. These include side effects such as elevated levels of liver toxins, gastrointestinal pain, acne, gynecomastia, increased aggressiveness, and high blood pressure.

Synthetic route

methylandrostenediol (521-10-8) + propionic acid anhydride (123-62-6) → methandriol dipropionate (3593-85-9)

Conditions	Yield
at 130 - 140℃;

methandriol dipropionate (3593-85-9) → propionic acid-(3β-hydroxy-17α-methyl-androsten-(5)-yl-(17β)-ester) (35800-60-3)

Conditions	Yield
With potassium hydroxide Hydrolysis;

methandriol dipropionate (3593-85-9) → 17α-methyl-17β-propionyloxy-androst-4-en-3-one (7600-58-0)

Conditions	Yield
Multi-step reaction with 2 steps 1: methanol. KOH / Hydrolysis 2: bromine; aqueous acetic acid; CrO3 / Reagens 4:Aether;Behandeln des Reaktionsprodukts mit Zink-Pulver und Essigsaeure View Scheme

Upstream product

• 521-10-8 methylandrostenediol 
• 123-62-6 propionic acid anhydride