35938-96-6Relevant academic research and scientific papers
Acetoacetanilides as masked isocyanates: Facile and efficient synthesis of unsymmetrically substituted ureas
Wei, Ying,Liu, Jing,Lin, Shaoxia,Ding, Hongqian,Liang, Fushun,Zhao, Baozhong
supporting information; experimental part, p. 4220 - 4223 (2010/11/04)
Figure Presented. A general and practical method for the preparation of unsymmetrically substituted ureas has been developed. By the reactions of acetoacetanilides with various amines including primary/secondary amines, a series of substituted aryl ureas were achieved in high yields. Acetoacetanilide substrates can be considered as masked reagents that liberate reactive isocyanates in situ.
