359434-49-4

Upstream product

• 78635-98-0 3'-O-levulinoylthymidine 
• 171974-08-6 C₆₁H₆₇N₄O₁₅PSi 
• 158852-07-4 5'-O-(4,4'-dimethoxytrityl)thymidine-3'-O-(2-diphenylmethylsilylethyl N,N-diisopropyl phosphoramidite) 
• 21090-30-2 3'-O-acetylthymidine 
• 171974-09-7 C₆₁H₆₇N₄O₁₅PSSi 
• 182966-92-3 C₅₈H₆₃N₄O₁₄PSSi 

Downstream Products

• 219692-88-3 C₃₅H₄₃N₄O₁₁PSSi 

Relevant academic research and scientific papers

Synthesis and deprotection of β-silylethyl protected O,O,O-and O,O,S-trialkylphosphorothioates

Functionalized 2-(diphenylmethylsilyl)ethyl protected thymidyl-thymidine phosphorothioate dimers are easily accessible and stable under conditions used in oligophosphorothioate synthesis. Deprotection with ammonium hydroxide occurs through β-fragmentation. Methylamine and tetrabutyl-ammonium fluoride rapidly and selectively remove the DPSE protecting group of O,O,O-and O,O,S-trialkylphosphorothioates.