35946-66-8Relevant academic research and scientific papers
Systematic Structural Characterization of Chitooligosaccharides Enabled by Automated Glycan Assembly
Bordoni, Vittorio,Chaube, Manishkumar A.,Delbianco, Martina,Fittolani, Giulio,Grafmüller, Andrea,Seeberger, Peter H.,Tyrikos-Ergas, Theodore
supporting information, p. 2321 - 2325 (2021/01/18)
Chitin, a polymer composed of β(1–4)-linked N-acetyl-glucosamine monomers, and its partially deacetylated analogue chitosan, are abundant biopolymers with outstanding mechanical as well as elastic properties. Their degradation products, chitooligosacchari
TOLL-LIKE RECEPTOR LIGANDS
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Paragraph 00301, (2019/08/29)
Toll-like receptor (TLR) ligands having an allose-based core are stable in aqueous formulation and are useful in treating, preventing, or reducing susceptibility to diseases or conditions mediated by TLRs, such as cancer, infectious disease, allergy, autoimmune disease, sepsis, and ischemia reperfusion.
MAGNETIC LABELING OF BACTERIA
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, (2014/01/08)
The present invention provides novel methods of magnetically labeling a bacterial cell by contacting the call with an affinity ligand and subsequently contacting the cell with a magnetic agent, where the affinity ligand and magnetic agent include bioorthogonally reactive groups that can react with each other to form a covalent bond. Compounds, compositions, kits and applications of the method are also described.
High-efficiency synthesis of chitooligosaccharides
Huang, Gangliang
scheme or table, p. 70 - 72 (2012/04/23)
The solid-phase synthesis of chitooligosaccharides is described. After the NHCbz trichloroacetimidate donors 6 and 14 were synthesized; solid-phase synthesis was performed using the Wang resin as support. The illustrated tetra-Nacetyl- chitotetraose 1 was
Solid-phase synthesis of Di-N-Acetyl-β-chitobiosyl NAG-thiazoline
Huang, Gangliang,Chen, Ya
scheme or table, p. 649 - 651 (2012/05/20)
The solid-phase synthesis of di-N-acetyl-β-chitobiosyl NAG (N-acetyl D-glucosamine)-thiazoline 3 was reported. After the 6-O-benzyl NAG-thiazoline 9, NHCbz trichloroacetimidate donors 14, and 21 were synthesized, and solid-phase synthesis was performed using the Wang resin as support. The target di-N-acetyl-β-chitobiosyl NAGthiazoline 3 was obtained by iterative glycosylation reactions, catalytic hydrogenation, acetylation, and deacetylation, respectively. donors, Wang resin, Glycosylation reactions.
Solid-phase synthesis of di-N-acetyl-β-chitobiosyl allosamizoline
Huang, Gangliang
scheme or table, p. 625 - 627 (2012/06/29)
The solid-phase synthesis of di-N-acetyl-β-chitobiosyl allosamizoline 2 was reported. After the 6-O-benzyl allosamizoline 16, NHCbz trichloroacetimidate donors 7, and 14 were synthesized; solid-phase synthesis was performed using the Wang resin as support. The target di-N-acetyl-β- chitobiosyl allosamizoline 2 was obtained by iterative glycosylation reactions, catalytic hydrogenation, acetylation, and deacetylation, respectively.
DETECTION OF MYCOBACTERIA
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, (2011/04/18)
A method for determining the presence of mycobacteria species in an organism or biological sample, the method comprising adding to the organism or biological sample a probe molecule comprising a substrate and a label, which probe molecule can be incorporated into mycobacteria, the presence of mycobacteria being determined by a detector responsive to the presence of the label, optionally after applying a stimulus; suitable probe molecules include compounds comprising a label and a substrate, which label is can be detected by a detector responsive to the presence of the label, optionally after applying a stimulus, characterised by compound being able to engage with the active site of Antigen 85B (Ag85B) such that it can form simultaneous hydrogen bonds with two or more amino acids in the active site selected from Arg 43, Trp 264, Ser126, His 262 and Leu 42, or the corresponding amino acids in Antigen 85A (Ag85A) or Antigen 85C (Ag85C), at least one of which is with Ser126.
Synthesis of D-glucosamine-modified benzo[d][1,2]selenazol-3-(2H)-one derivatives
Zhang, Zhongwei,Ren, Sumei,Wan, Shengbiao,Li, Wei,Jiang, Tao
scheme or table, p. 3438 - 3446 (2011/01/12)
A new class of organoselenium-saccharide derivatives, 2-amino-2-deoxy - D-glucose-modified benzo[d][1,2]selenazol-3-(2H)-one derivatives, has been synthesized via the cyclization reaction of 2-(chloroseleno)benzoyl chloride and O-protected D-glucosamine derivatives. An efficient synthetic method for the preparation of this type of compounds was developed. It has been found that acetone can react with the chloroseleno group under basic conditions, and organoselenium-saccharide derivatives with free hydroxy groups were obtained only when the OH-1 group of the saccharide was protected. Copyright Taylor & Francis Group, LLC.
Versatile acetylation of carbohydrate substrates with bench-top sulfonic acids and application to one-pot syntheses of peracetylated thioglycosides
Chao, Chin-Sheng,Chen, Min-Chun,Lin, Shih-Che,Mong, Kwok-Kong T.
, p. 957 - 964 (2008/09/17)
Inexpensive and readily available sulfonic acids, p-toluenesulfonic acid, and sulfuric acid are versatile and efficient catalysts for the peracetylation of a broad spectrum of carbohydrate substrates in good yield and in a practical time frame. Three appealing features in sulfonic acid-catalyzed acetylation of free sugars were explored including (1) suppression of furanosyl acetate formation for d-galactose and l-fucose; (2) high yielding chemoselective acetylation of sialic acid under appropriate conditions; and (3) peracetylation of amino sugars with different amino protecting functions. Simple one-pot two step acetylation-thioglycosidation methods for the expeditious synthesis of p-tolyl per-O-acetyl thioglycosides were also delineated.
Synthesis of components for the generation of constitutional dynamic analogues of nucleic acids
Hickman, David T.,Sreenivasachary, Nampally,Lehn, Jean-Marie
, p. 1 - 20 (2008/04/12)
The introduction of dynamic covalent polymers, in which the monomer units are linked by reversible covalent bonds and can undergo component exchange, opens up new possibilities for the generation of functional materials. Extending this approach to the gen
