99194-76-0

Upstream product

• 35946-66-8 2-(acetoxymethyl)-5-{[(benzyloxy)carbonyl]amino}tetrahydropyran-3,4,6-triyl triacetate 
• 51471-40-0 2--2-deoxy-D-glucopyranose 
• 114297-26-6 1,3,4,6-tetra-O-acetyl-2-deoxy-2-{[(4-methoxyphenyl)methylidene]amino}-D-glucopyranose 
• 501-53-1 benzyl chloroformate 
• 5432-46-2 acetyl 3,4,6-tri-O-acetyl-2-amino-2-deoxy-D-glucopyranoside hydrochloride 
• 5348-99-2 1,3,4,6-tetra-O-acetyl-2-deoxy-2-(benzyloxycarbonyl)amino-α/β-D-glucopyranoside 
• 3006-58-4 2-carbobenzyloxyamino-2-deoxy-D-glucopyranose 
• 1078691-95-8 (+)-D-glucosamine hydrochloride 
• 73446-41-0 3,4,6-tri-O-acetyl-2-(benzoyloxycarbonyl)amino-2-deoxy-α-D-glucopyranosyl bromide 
• 121785-09-9 benzyl ((2R,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)carbamate 
• 14131-63-6 D-glucosamine hydrochloride 

Downstream Products

• 1301718-53-5 C₂₂H₂₅Cl₃N₂O₁₀ 
• 99194-78-2 1-O-(3,4,6-tri-O-acetyl-2-benzyloxycarbonylamino-2-deoxy-β-D-glucopyranosyl)-4'-O-benzyloxycarbonyl-4'-O-demethyl-1-epipodophyllotoxin 
• 99194-78-2 1-O-(3,4,6-tri-O-acetyl-2-benzyloxycarbonylamino-2-deoxy-α-D-glucopyranosyl)-4'-O-benzyloxycarbonyl-4'-O-demethyl-1-epipodophyllotoxin 
• 816451-36-2 tert-butyldimethylsilyl 3,4,6-tri-O-acetyl-2-(benzyloxycarbonyl)amino-2-deoxy-β-D-glucopyranoside 
• 1274877-74-5 3,4,6,7-tetra-O-benzyl-1-deoxy-α-D-gluco-hept-2-ulopyranosyl-(2-1)-3,4,6-tri-O-acetyl-2-deoxy-2-benzylcarbamate-β-D-glucopyranoside 
• 1274877-71-2 3,4,6,7-tetra-O-benzyl-1-deoxy-α-D-gluco-hept-2-ulopyranosyl-(2-1)-3,4,6-tri-O-acetyl-2-deoxy-2-benzylcarbamate-α-D-glucopyranoside 
• 1313741-19-3 C₄₉H₅₅NO₁₂ 
• 1301718-54-6 TBDMS 2-deoxy-2-(N-benzyloxycarbonylamino)-β-D-glucopyranoside 
• 1301718-58-0 C₃₀H₃₃Cl₃N₂O₁₀ 
• 1301718-57-9 C₃₄H₄₇NO₁₀Si 
• 1301718-56-8 C₂₉H₄₁NO₈Si 
• 140183-60-4 Acetic acid (1R,2R,3S,4R,5S)-2-acetoxy-3-acetoxymethyl-4-benzyloxyamino-5-benzyloxycarbonylamino-cyclopentyl ester 
• 140183-60-4 Acetic acid (1R,2R,3R,5S)-2-acetoxy-3-acetoxymethyl-4-benzyloxyamino-5-benzyloxycarbonylamino-cyclopentyl ester 
• 140183-57-9 2-benzyloxycarbonylamino-2-deoxy-3,4,6-tri-O-acetyl-5-phenoxy(thiocarbonyl)oxy-D-glucose O-benzyl oxime 

Relevant academic research and scientific papers

Synthesis of the fungal lipo-chitooligosaccharide Myc-IV (C16:0, S), symbiotic signal of arbuscular mycorrhiza

A new synthesis of the fungal lipo-chitooligosaccharide Myc-IV (C16:0, S), which was recently reported to be a major symbiotic signalling molecule in arbuscular mycorrhiza, is described. Key steps include the oxidative cleavage of a 4,6-O-benzylidene acet

MAGNETIC LABELING OF BACTERIA

The present invention provides novel methods of magnetically labeling a bacterial cell by contacting the call with an affinity ligand and subsequently contacting the cell with a magnetic agent, where the affinity ligand and magnetic agent include bioorthogonally reactive groups that can react with each other to form a covalent bond. Compounds, compositions, kits and applications of the method are also described.

DETECTION OF MYCOBACTERIA

A method for determining the presence of mycobacteria species in an organism or biological sample, the method comprising adding to the organism or biological sample a probe molecule comprising a substrate and a label, which probe molecule can be incorporated into mycobacteria, the presence of mycobacteria being determined by a detector responsive to the presence of the label, optionally after applying a stimulus; suitable probe molecules include compounds comprising a label and a substrate, which label is can be detected by a detector responsive to the presence of the label, optionally after applying a stimulus, characterised by compound being able to engage with the active site of Antigen 85B (Ag85B) such that it can form simultaneous hydrogen bonds with two or more amino acids in the active site selected from Arg 43, Trp 264, Ser126, His 262 and Leu 42, or the corresponding amino acids in Antigen 85A (Ag85A) or Antigen 85C (Ag85C), at least one of which is with Ser126.

High-efficiency synthesis of chitooligosaccharides

The solid-phase synthesis of chitooligosaccharides is described. After the NHCbz trichloroacetimidate donors 6 and 14 were synthesized; solid-phase synthesis was performed using the Wang resin as support. The illustrated tetra-Nacetyl- chitotetraose 1 was

Solid-phase synthesis of di-N-acetyl-β-chitobiosyl allosamizoline

The solid-phase synthesis of di-N-acetyl-β-chitobiosyl allosamizoline 2 was reported. After the 6-O-benzyl allosamizoline 16, NHCbz trichloroacetimidate donors 7, and 14 were synthesized; solid-phase synthesis was performed using the Wang resin as support. The target di-N-acetyl-β- chitobiosyl allosamizoline 2 was obtained by iterative glycosylation reactions, catalytic hydrogenation, acetylation, and deacetylation, respectively.

Solid-phase synthesis of Di-N-Acetyl-β-chitobiosyl NAG-thiazoline

The solid-phase synthesis of di-N-acetyl-β-chitobiosyl NAG (N-acetyl D-glucosamine)-thiazoline 3 was reported. After the 6-O-benzyl NAG-thiazoline 9, NHCbz trichloroacetimidate donors 14, and 21 were synthesized, and solid-phase synthesis was performed using the Wang resin as support. The target di-N-acetyl-β-chitobiosyl NAGthiazoline 3 was obtained by iterative glycosylation reactions, catalytic hydrogenation, acetylation, and deacetylation, respectively. donors, Wang resin, Glycosylation reactions.

Towards a modular synthesis of well-defined chitooligosaccharides: Synthesis of the four chitodisaccharides

The total chemical synthesis of the four well-defined chitodisaccharides is described using N-trichloroacetyl (TCA) and N-benzyloxycarbonyl (Z) as C-2 protecting groups for acetamido and free amino groups, respectively. The synthesis is carried out accord

Systematic synthesis of bisubstrate-type inhibitors of TV- acetylglucosaminyltransferases

Bisubstrate-type inhibitors for N-acetylglucosaminyltransferase (GnT)-V and -IX were designed and synthesized. These compounds carry both an acceptor trisaccaride and an UDP-GlcNAc component tethered by a linker of variable length. The acceptor trisaccharide unit was constructed using a combination of a polymer support and a resin capture-release strategy. Namely, starting with a β-mannoside bound to low molecular weight monomethyl PEG (MPEG), successive glycosylations with donors having chloroacetyl group produced the trisaccharide, which was subjected to the capture-release purification using cysteine loaded resin. UDP-GlcNAc units carrying phosphate moieties were separately synthesized from the bromoacetamide-containing glucosamine derivative. Ligation between the acceptor thiol and each alkyl bromide on the donor unit readily proceeded, and produced the coupling product. The introduction of the UMP component gave target compounds. All of the synthesized compounds had significant activities to GnT-V and -IX. Their potencies were dependent upon the linkers length. GnT-IX was more sensitive to these inhibitors and optimum linker length was clearly different between these GnTs. The most potent inhibitor of GnT-V had Ki = 18.3 μM, while that of GnT-IX had Ki = 4.7 μM.

Synthesis of a bisubstrate-type inhibitor of N- acetylglucosaminyltransferases

Transfer interference: Synthesis of the bisubstrate-type N-acetylglucosaminyltransferase (GnT) inhibitor 1 was achieved by a polymer-resin hybrid capture-release strategy for the construction of the acceptor component. One-pot ligation in aqueous media pr

An Enantiospecific Synthesis of Allosamizoline

An enantiospecific synthesis of allosamizoline 4, the aglycone of the chitinase inhibitor allosamidin 3, has been achieved, starting from readily available glucosamine.The key step in the synthesis involves the cyclisation of a carbon-centred radical onto