35959-93-4Relevant articles and documents
Structure-activity relationship and multidrug resistance study of new S-trityl-L-cysteine derivatives as inhibitors of Eg5
Kaan, Hung Yi Kristal,Weiss, Johanna,Menger, Dominik,Ulaganathan, Venkatasubramanian,Tkocz, Katarzyna,Laggner, Christian,Popowycz, Florence,Joseph, Beno?t,Kozielski, Frank
supporting information; experimental part, p. 1576 - 1586 (2011/06/27)
The mitotic spindle is a validated target for cancer chemotherapy. Drugs such as taxanes and vinca alkaloids specifically target microtubules and cause the mitotic spindle to collapse. However, toxicity and resistance are problems associated with these dr