35963-91-8Relevant articles and documents
The synthesis, structure-toxicity relationship of cisplatin derivatives for the mechanism research of cisplatin-induced nephrotoxicity
Hu, Jing,Wu, Tian-Ming,Li, Hong-Ze,Zuo, Ze-Ping,Zhao, Ying-Lan,Yang, Li
, p. 3591 - 3594 (2017)
Cisplatin is a widely used antineoplastic drug, while its nephrotoxicity limits the clinical application. Although several mechanisms contributing to nephrotoxicity have been reported, the direct protein targets are unclear. Herein we reported the synthesis of 29 cisplatin derivatives and the structure-toxicity relationship (STR) of these compounds with MTT assay in human renal proximal tubule cells (HK-2) and pig kidney epithelial cells (LLC-PK1). To the best of our knowledge, this study represented the first report regarding the structure-toxicity relationship (STR) of cisplatin derivatives. The potency of biotin-pyridine conjugated derivative 3 met the requirement for target identification, and the preliminary chemical proteomics results suggested that it is a promising tool for further target identification of cisplatin-induced nephrotoxicity.
Synthesis, spectroscopic characterization and catalytic activity of platinum(II) carbene complexes
Bolbat, Ekaterina,Suarez-Alcantara, Karina,Canton, Sophie E.,Wendt, Ola F.
, p. 129 - 133 (2016/03/12)
A novel platinum complex with 1,3-bis(2,6-diisopropylphenyl)-1,3-dihydro-2H-imidazol-2-ylidenyl ligand has been synthesized and characterized on the basis of elemental analysis, MS, 1H and 13C NMR spectroscopy, X-ray Absorption Spect
Supramolecular chemistry of halogens: Complementary features of inorganic (M-X) and organic (C-X′) halogens applied to M-X...X′-C halogen bond formation
Zordan, Fiorenzo,Brammer, Lee,Sherwood, Paul
, p. 5979 - 5989 (2007/10/03)
Electronic differences between inorganic (M-X) and organic (C-X) halogens in conjunction with the anisotropic charge distribution associated with terminal halogens have been exploited in supramolecular synthesis based upon intermolecular M-X...X′-C halogen bonds. The synthesis and crystal structures of a family of compounds trans-[MCl2(NC5H 4X-3)2] (M = Pd(II), Pt(II); X = F, Cl, Br, I; NC 5H4X-3 = 3-halopyridine) are reported. With the exception of the fluoropyridine compounds, network structures propagated by M-Cl...X-C halogen bonds are adopted and involve all M-Cl and all C-X groups, M-Cl...X-C interactions show Cl...X separations shorter than van der Waals values, shorter distances being observed for heavier halogens (X). Geometries with near linear Cl...X-C angles (155-172°) and markedly bent M-Cl...X angles (92-137°) are consistently observed. DR calculations on the model dimers {trans-[MCl2(NH3)(NC 5H4X-3)]}2 show association through M-Cl...X-C (X ≠ F) interactions with geometries similar to experimental values. DFT calculations of the electrostatic potential distributions for the compounds trans-[PdCl2(NC5H4X-3)2] (X = F, Cl, Br, I) demonstrate the effectiveness of the strategy to activate C-X groups toward halogen bond formation by enhancing their electrophilicity, and explain the absence of M-Cl...F-C interactions. The M-Cl...X-C halogen bonds described here can be viewed unambiguously as nucleophile-electrophile interactions that involve an attractive electrostatic contribution. This contrasts with some types of halogen-halogen interactions previously described and suggests that M-Cl...X-C halogen bonds could provide a valuable new synthon for supramolecular chemists.
