35969-50-7Relevant articles and documents
Application of organolithium and related reagents in synthesis. Part XI. Metallation of 2-methyl- and 4-methylnicotinic acids. A useful method for preparation of aza-isocoumarins
Epsztajn,Plotka,Scianowski
, p. 1239 - 1247 (2007/10/02)
The metallation (LDA/THF) of 2-methyl- and 4-methylnicotinic acids (1) and (2), and the subsequent reaction of the lithiated species (3) and (4) with carbonyl electrophiles as a synthetic route of 5-aza- and 7-aza-isocoumarins (7), (8), (9) and (10), is d