35969-50-7

Upstream product

• 133390-61-1 N-Propyl-2-phenacylpyridine-3-carboxamide 
• 5657-54-5 7-Phenyl-5H-pyrano<4,3-b>pyridin-5-one 
• 118159-94-7 2-phenylethynylpyridine-3-carbonitrile 
• 3222-56-8 2-methylnicotinic acid 
• 611-74-5 N,N-dimethylbenzamide 

Downstream Products

• 5657-54-5 7-Phenyl-5H-pyrano<4,3-b>pyridin-5-one 
• 141693-15-4 2-(2'-hydroxyethyl)-3-phenyl-1,2-dihydro-2,5-naphthyridin-1-one 

Relevant academic research and scientific papers

Application of organolithium and related reagents in synthesis. Part XI. Metallation of 2-methyl- and 4-methylnicotinic acids. A useful method for preparation of aza-isocoumarins

The metallation (LDA/THF) of 2-methyl- and 4-methylnicotinic acids (1) and (2), and the subsequent reaction of the lithiated species (3) and (4) with carbonyl electrophiles as a synthetic route of 5-aza- and 7-aza-isocoumarins (7), (8), (9) and (10), is d

A facile synthesis of 1,6-naphthyridin-5(6H)-ones

3-Cyano-2-(phenylethynyl)pyridine (1) was cyclized intramolecularly under acidic conditions to give 1,6-naphthyridin-5(6H)-one (2) and 5H-pyrano[4,3-b]pyridine-5-one (4). Pyranopyridine 4 was readily transformed to 2 or naphthyridinone 9 having an alkyl substituent at 6-position.