118159-94-7

Basic information

• Product Name: 2-phenylethynylpyridine-3-carbonitrile
• Synonyms: 2-phenylethynylpyridine-3-carbonitrile
• CAS NO: 118159-94-7
• Molecular Formula: C₁₄H₈N₂
• Molecular Weight: 204
• Mol File: 118159-94-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-phenylethynylpyridine-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenylethynylpyridine-3-carbonitrile(118159-94-7)
• EPA Substance Registry System: 2-phenylethynylpyridine-3-carbonitrile(118159-94-7)

Safety Data

• Hazardous Substances Data: 118159-94-7(Hazardous Substances Data)

Upstream product

• 14906-64-0 3-cyanopyridine N-oxide 
• 100-54-9 pyridine-3-carbonitrile 
• 591-50-4 iodobenzene 
• 74-86-2 acetylene 
• 6602-54-6 2-chloro-3-pyridinecarbonitrile 
• 20577-27-9 pyrid-2-one-3-carbonitrile 
• 20577-26-8 2-bromonicotinonitrile 
• 536-74-3 phenylacetylene 

Downstream Products

• 35969-50-7 2-Phenacylpyridine-3-carboxylic acid 
• 5657-54-5 7-Phenyl-5H-pyrano<4,3-b>pyridin-5-one 
• 131169-59-0 6,7-dihydro-7-benzyl-7-hydroxy-5H-furo<3,4-b>pyridin-5-one 
• 35969-62-1 7-phenyl-1,6-naphthyridin-5-one 
• 1613435-77-0 1-methyl-5-oxo-7-phenyl-1,6-naphthyridinium iodide 
• 1613435-75-8 7-phenyl-1,6-naphthyridin-5-one 1-oxide 
• 1260150-44-4 C₁₆H₁₄N₂O 
• 133390-61-1 N-Propyl-2-phenacylpyridine-3-carboxamide 
• 133390-62-2 7-Phenyl-6-propyl-1,6-naphthyridin-5(6H)-one 
• 133390-60-0 7,8-Dihydro-7-hydroxy-7-phenyl-1,6-naphthyridin-5(6H)-one 
• 26933-59-5 6,7-dihydro-7-benzylidene-5H-furo<3,4-b>pyridin-5-one 

Relevant articles and documents

Method for preparing phenyl-2-(2'-cyanophenyl) acetylene compound through palladium catalysis

The invention discloses a method for preparing a phenyl-2-(2'-cyanophenyl) acetylene compound shown as a formula (IV) through palladium catalysis. The preparation method comprises the following steps:taking palladium chloride as a catalyst, sodium carbonate as an alkali and dimethyl sulfoxide as a solvent, carrying out sufficient reactions in the presence of oxygen, and carrying out after-treatment on the reaction product to obtain the phenyl-2-(2'-cyanophenyl) acetylene compound, wherein the benzonitrile compound is shown as a formula (I), acetylene is shown as a formula (II), and the iodobenzene compound is shown as a formula (III). The method is efficient and meets the green and environment-friendly requirements; and the catalytic system has wide adaptability and is suitable for large-scale production of pharmaceutical and chemical intermediates.

TANKYRASE INHIBITORS

The present invention relates to a compound of formula I wherein X is C(R6) or N, Y is C or N, and ring A, ring B, R1 and R2 have the meanings defined herein, provided that when ring B is carbocyclic, X is C(R6); or a pharmaceutically acceptable salt or solvate thereof. The compounds are tankyrase-1 and tankyrase-2 inhibitors and are useful in the treatment of a number of conditions, including cancer.

Condensed Heteroaromatic Ring Systems. XV. Synthesis of Pyranopyridinones from Halopyridinecarbonitriles

Four kinds of pyranopyridinones were synthesized from pyridinecarbonitriles containing a chlorine or bromine substituent at the adjacent position to the cyano group by the palladium-catalyzed cross-coupling reaction with terminal acetylenes followed by in