359700-09-7

Upstream product

• 388631-93-4 (E)-tert-butyl 3-(3-methoxy-3-oxoprop-1-en-1-yl)-1H-indole-1-carboxylate 
• 19626-92-7 trans-3-(3-indolyl)acrylsaeuremethylester 
• 1204-06-4 trans-3-indole-acrylic acid 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 876307-10-7 tert-butyl 3-((1E)-3-oxo-3-((4R)-2-oxo-phenyloxazolidin-3-yl)prop-1-en-1-yl)-1H-indole-1-carboxylate 
• 1569645-11-9 (E)-tert-butyl 3-(3-(2-(4-fluorobenzoyl)-1-isopropylhydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate 
• 1407499-53-9 (E)-tert-butyl 3-(3-(2-(3-fluorobenzoyl)-1-isopropylhydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate 
• 1407499-58-4 (E)-tert-butyl 3-(3-(2-(3-(2-amino-2-oxoethoxy)benzoyl)-1-isopropylhydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate 
• 1407499-73-3 (E)-tert-butyl 3-(3-(2-(4-(2-bromoethoxy)benzoyl)-1-isopropylhydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate 
• 1407499-72-2 (E)-tert-butyl 3-(3-(2-(3-(2-bromoethoxy)benzoyl)-1-isopropylhydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate 
• 1407499-39-1 (E)-tert-butyl 3-(3-(2-benzoyl-1-isopropylhydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate 
• 1407499-54-0 (E)-tert-butyl 3-(3-(2-benzoylhydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate 
• 1407499-52-8 (E)-tert-butyl 3-(3-(2-(4-chlorobenzoyl)-1-isopropylhydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate 
• 1407499-51-7 (E)-tert-butyl 3-(3-(2-(4-bromobenzoyl)-1-isopropylhydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate 
• 1407499-50-6 (E)-tert-butyl 3-(3-(2-(3-bromobenzoyl)-1-isopropylhydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate 
• 1407499-57-3 (E)-2-(3-(2-(3-(1-(tert-butoxycarbonyl)-1H-indol-3-yl)acryloyl)-2-isopropylhydrazinecarbonyl)phenoxy)acetic acid 
• 1407499-56-2 (E)-tert-butyl 3-(3-(1-isopropyl-2-(3-(2-methoxy-2-oxoethoxy)benzoyl)hydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate 
• 1407499-49-3 (E)-tert-butyl 3-(3-(1-isopropyl-2-(4-(2-methoxyethoxy)benzoyl)hydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate 

Relevant academic research and scientific papers

MULTIBIOTIC AGENTS AND METHODS OF USING THE SAME

Multibiotic agents are disclosed. The multibiotic agents may contain two or more moieties linked through bonds cleavable in vivo. The bonds cleavable in vivo can be ester bonds, amide bonds, azo bonds, glycosidic bonds, carbonate linkers, or carbamate linkers. The moieties can be alcohol cores, amine cores, and/or acyls. Also disclosed are compositions containing multibiotic agents and methods of using the multibiotic agents.

Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions

The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.

Discovery of a novel series of indolyl hydrazide derivatives as diacylglycerol acyltransferase-1 inhibitors

A novel series of hydrazide derivatives were synthesized as potential diacylglycerol acyltransferase (DGAT) inhibitors. Among them, compounds 8u and 8v exhibited selective and potent DGAT-1 inhibitory activities. In addition, compound 8u dose-dependently inhibited triglyceride synthesis in HepG2 cell lines. Furthermore, treatment with compound 8u for an oral lipid tolerance test showed a significant decrease in plasma triglyceride levels compared with vehicle-treated control animals, indicating delayed absorption of triglyceride after an acute lipid challenge.

Synthesis of (2S,3S)-β-methyltryptophan

Nα-Fmoc-protected (2S,3S)-β-methyltryptophan has been synthesized by asymmetric synthesis through the aid of an oxazolidinone auxiliary. Coupling of the mixed anhydride of Nin-Boc-protected indoleacrylic acid to the oxazolidinone auxiliary was achieved by lithium bromide and N,N-dimethylpyridine (DMAP). This reaction is milder and more convenient to run than the traditional conditions using butyl lithium.