359792-91-9

Basic information

• Product Name: 1H-Imidazo[4,5-b]pyrazine,1-(methoxymethyl)-(9CI)
• Synonyms: 1H-Imidazo[4,5-b]pyrazine,1-(methoxymethyl)-(9CI)
• CAS NO: 359792-91-9
• Molecular Formula: C7H8N4O
• Molecular Weight: 164.16462
• Product Categories: AMINETERTIARY
• Mol File: 359792-91-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Imidazo[4,5-b]pyrazine,1-(methoxymethyl)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazo[4,5-b]pyrazine,1-(methoxymethyl)-(9CI)(359792-91-9)
• EPA Substance Registry System: 1H-Imidazo[4,5-b]pyrazine,1-(methoxymethyl)-(9CI)(359792-91-9)

Safety Data

• Hazardous Substances Data: 359792-91-9(Hazardous Substances Data)

Upstream product

• 273-94-9 1H-imidazo[4,5-d]pyrazine 
• 107-30-2 chloromethyl methyl ether 

Downstream Products

• 361382-81-2 2-amino-1H-imidazo[4,5-b]pyrazine 

Relevant articles and documents

Dienophilicity of imidazole in inverse electron demand Diels-Alder reactions: Cycloadditions with 1,2,4,5-tetrazines and the structure of zarzissine

The inverse electron demand cycloadditions of 2-substituted imidazoles with dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate produced imidazo[4,5-d]pyridazines in good yields. This chemistry was applied to the synthesis of 2-amino-1H-imidazo[4,5-d]pyridazine (1), the structure reported for zarzissine, a cytotoxic marine alkaloid. Differences in the 1H- and 13C NMR spectra of 1 with those reported for zarzissine necessitated a structural revision, and zarzissine was then considered to be the corresponding 2-amino-1H-imidazo[4,5-b]pyrazine (2), which was subsequently synthesized from the parent heterocycle.