3598-68-3

Usage

Uses

3-Nitromethylphthalide (cas# 3598-68-3) is a compound useful in organic synthesis.

InChI:InChI=1/C9H7NO4/c11-9-7-4-2-1-3-6(7)8(14-9)5-10(12)13/h1-4,8H,5H2/t8-/m0/s1

Upstream product

• 75-52-5 nitromethane 
• 119-67-5 o-carboxybenzaldehyde 
• 16859-59-9 3-hydroxy-1(3H)-isobenzofuranone 

Downstream Products

• 97049-76-8 methyl (E)-2-(2-nitrovinyl)benzoate 
• 82359-81-7 2,3-dihydro-3-methylene-2-benzyl-1H-isoindolone 
• 35690-69-8 3-aminomethyl-phthalide; hydrochloride 
• 115912-92-0 2-(2-nitroethyl)benzoic acid 
• 97049-84-8 3-(aminomethyl)-2-3-dihydro-2-(phenylmethyl)-1H-isoindol-1-one 
• 97049-78-0 2,3-dihydro-3(nitromethyl)-2-phenylmethyl-1H-isoindol-1-one 

Relevant academic research and scientific papers

(3aR,9bS)-tert-butyl-3,3a,5,9b-tetrahydro-1hydrogen-pyrrole[3,4-c]isoquinoline-4(2hydrogen)-carboxylic ester

The invention relates to a preparation method of (3aR,9bS)-tert-butyl-3,3a,5,9b-tetrahydro-1hydrogen-pyrrole[3,4-c]isoquinoline-4(2hydrogen)-carboxylic ester. The technical problem that there is no method suitable for industrial synthesis of the above compound at present is mainly solved. The preparation method comprises the following seven steps: Step 1, a compound 1 and nitromethane react under the alkaline condition to obtain a compound 2; Step 2, the compound 2 and dimethyl carbonate react to obtain a compound 3; Step 3, a [3+2] reaction between the compound 3 and a compound 8 is carried out to obtain a compound 4; Step 4, the compound 4 undergoes raney nickel reduction and the product directly reacts with MeONa to obtain a compound 5; Step 5, the compound 5 undergoes LiAlH reduction to obtain a compound 6; Step 6, the compound 6 reacts with Boc anhydride to obtain a compound 7; and Step 7, hydrogenation debenzylation is finally carried out to obtain the final product, namely a compound 9. The compound obtained by the preparation method is a useful intermediate or a product synthesized by many medicines.

A New Procedure for Regiospecific Syntheses of Benzopyran-1-ones

A new, general route to benzopyran-1-ones 33 from phthalaldehydic acids 27 and nitroalkanes 28 is described.The sequence permits strightforward variation of both the 3-substituent and the pattern of functionalization on the aromatic ring of the benzopyran

1-Ethoxy-3,4-dihydroisoquindines

1-(2-Substituted-hydrazino)-3,4-dihydroisoquinolines, prepared in one process by alkylating the corresponding 3,4-dihydroisocarbostyrils, hydrazinolyzing the resulting 1-alkoxy-3,4-dihydroisoquinolines and condensing the resulting 1-hydrazIno-3,4-dihydroisoquinolines with aldehydes or ketones, and 1,1'-azinobis(1,2,3,4-tetrahydroisoquinolines), prepared by condensing corresponding 1-alkoxy-3,4-dihydroisoquinolines and 1-hydrazino-3,4-dihydroisoquinolines, are useful as antihypertensive agents and/or as antiinflammatory agents.

Research on antitumor chemotherapy: X. β Nitrostyrene and nitrovinyl derivatives

In previous work, the antitumoral cytotoxicity of β nitrostyrenes obtained by simplification of the aristolochic acid molecule was demonstrated. The effect of modifying the 3 characteristic parts of the β nitrostyrene molecule was then investigated. Results in vitro and in vivo indicate a probable mechanism of action for the β nitrostyrene and nitrovinyl compounds studied, and permit definition of the maximum simplification compatible with retention of biological activity.