359863-41-5Relevant academic research and scientific papers
3-(diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives
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, (2008/06/13)
This invention is directed to 3-(diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives useful as δ-opioid or μ-opioid receptor modulators. Depending on their agonist or antagonist effect, the compounds are useful analgesics, immunosuppressants, antiinflammatory agents, agents for the treatment of neurological and psychiatric conditions, medicaments for drug and alcohol abuse, agents for treating gastritis and diarrhea, cardiovascular agents and agents for the treatment of respiratory diseases.
N,N-Dialkyl-4-[(8-azabicyclo[3.2.1]-oct-3-ylidene)phenylmethyl]benzamides, potent, selective δ opioid agonists
Carson, John R.,Coats, Steven J.,Codd, Ellen E.,Dax, Scott L.,Lee, Jung,Martinez, Rebecca P.,Neilson, Lou Anne,Pitis, Philip M.,Zhang, Sui-Po
, p. 2109 - 2112 (2007/10/03)
A series of N,N-dialkyl-4-(9-aryltropanylidenemethyl)benzamides was prepared. The lead compounds, 15a and 15c, exhibited extremely high affinity for the δ opioid receptor with excellent selectivity versus the μ opioid receptor. They were full agonists at
3-(diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives
-
, (2008/06/13)
This invention is directed to 3-(diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives useful as δ-opioid or μ-opioid receptor modulators. Depending on their agonist or antagonist effect, the compounds are useful analgesics, immunosuppressants, antiinflammatory agents, agents for the treatment of neurological and psychiatric conditions, medicaments for drug and alcohol abuse, agents for treating gastritis and diarrhea, cardiovascular agents and agents for the treatment of respiratory diseases.
