83507-66-8Relevant academic research and scientific papers
A fragment-based approach towards the discovery of N-substituted tropinones as inhibitors of Mycobacterium tuberculosis transcriptional regulator EthR2
Prevet, Hugues,Moune, Martin,Tanina, Abdalkarim,Kemmer, Christian,Herledan, Adrien,Frita, Rosangela,Wohlk?nig, Alexandre,Bourotte, Marilyne,Villemagne, Baptiste,Leroux, Florence,Gitzinger, Marc,Baulard, Alain R.,Déprez, Benoit,Wintjens, René,Willand, Nicolas,Flipo, Marion
, p. 426 - 438 (2019/02/20)
Tuberculosis (TB) caused by the pathogen Mycobacterium tuberculosis, represents one of the most challenging threat to public health worldwide, and with the increasing resistance to approved TB drugs, it is needed to develop new strategies to address this
Efficient, two-step synthesis of N-substituted nortropinone derivatives
Willand, Nicolas,Folléas, Benoit,Boutillon, Christophe,Verbraeken, Liesbeth,Gesquière, Jean-Claude,Tartar, André,Deprez, Benoit
, p. 5007 - 5011 (2008/02/10)
We describe a novel strategy for the synthesis of N-substituted nortropinone derivatives starting from tropinone. The key step of our synthesis is a reactivity umpolung of tropinone, which yields 8,8-dimethyl-3-oxo-8-azonia-bicyclo[3.2.1]octane iodide (IDABO) as a stable and convenient synthetic equivalent of cycloheptadienone.
