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Upstream product

• 220416-57-9 2-((1S)-1-((1E)-1,2-dichloroethenyloxy)ethyl)-1,3,5-triisopropylbenzene 
• 102225-88-7 (-)-(S)-1-(2,4,6-triisopropylphenyl)ethanol 
• 359866-19-6 2-[(S)-1-(hex-5-en-1-ynyloxy)ethyl]-1,3,5-triisopropylbenzene 

Relevant academic research and scientific papers

Enantiocontrolled preparation of indolizidines: Synthesis of (-)-2-epilentiginosine and (+)-lentiginosine

A highly stereoselective approach to (-)-2-epilentiginosine and (+)-lentiginosine has been developed based on a diastereofacially selective cycloaddition of dichloroketene with a chiral dienol ether. The two naturally occurring indolizidines are each obtained enantioselectively (≥ 99:1) in ca. 8.5% overall yield.